Purpose of the study While unconjugated hyperbilirubinemia is associated with the use of ritonavir-boosted atazanavir (ATV/r), the nature of the hyperbilirubinemia over time and its clinical significance has not been well-characterized in controlled studies. The purpose of this study is to describe the patterns and clinical significance of hyperbilirubinemia in patients treated with ATV/r in th...

OBJECTIVE. The purpose of this work was to compare the predictive accuracy of alternative risk-assessment strategies used to screen for the risk of significant neonatal hyperbilirubinemia. PATIENTS AND METHODS.We conducted a prospective cohort study of 823 term and nearterm newborns admitted to the well-infant nursery at the Hospital of the University of Pennsylvania. Maternal, infant, and deli...

OBJECTIVE Low antioxidant system may contribute to the severity of neonatal hyperbilirubinemia. The aim of this research was to explore the relationship between plasma vitamin E and C levels and the severity of hyperbilirubinemia in full-term neonates with normal glucose 6-phosphate dehydrogenase (G6PD) activities. METHODS A total of 130 full-term healthy live birth neonates of healthy mother...

Objective: To determine accuracy of cord blood bilirubin in identifying significant neonatal hyperbilirubinemia. Methodology: A Cross sectional study was conducted Pediatric department Fauji Foundation Hospital Rawalpindi from Jan.2019 to June 2019. Cord samples were sent for the group and levels. Neonates with level > 2mg/dl < 5 mg/dl enrolled admitted 3 days serum done on 3rd day. Those...

General pediatric care providers are exposed to clinical hepatology beginning with the care of newborns with indirect and direct hyperbilirubinemia. Indirect hyperbilirubinemia commonly involves “physiological” jaundice, breast-feeding and breast-milk jaundice, and jaundice secondary to hemolytic disease and resolves without potential lifelong or life-threatening disease. However, when practiti...

Jaundice in an adult patient can be caused by a wide variety of benign or life-threatening disorders. Organizing the differential diagnosis by prehepatic, intrahepatic, and posthepatic causes may help make the work-up more manageable. Prehepatic causes of jaundice include hemolysis and hematoma resorption, which lead to elevated levels of unconjugated (indirect) bilirubin. Intrahepatic disorder...

BACKGROUND Hyperbilirubinemia is a common disorder during neonatal period in Taiwan. Gene variants may play an important role in the development of neonatal hyperbilirubinemia. The current study investigated the association between neonatal hyperbilirubinemia and common gene variants involving the production and metabolism of bilirubin. METHODS This prospective study enrolled 444 healthy infa...

Background: Deferring the umbilical cord clamping produces more satisfactory neurological and hematological outcomes. Another alternative for deferred is milking. Objectives: This study aimed to evaluate different placental transfusion techniques in terms of parameters term neonates. Methods: observational included 120 infants assigned groups 60 seconds (DCC), cut milking four times with a spee...

Severe neonatal unconjugated hyperbilirubinemia, with the risk of bilirubin encephalopathy or kernicterus in severe, untreated cases, occurs when bilirubin production exceeds the body's ability to eliminate it. The causes of neonatal hyperbilirubinemia are multifactorial and comprise increased hemolysis on the one hand, and diminished bilirubin conjugation on the other. In recent years, many of...