The mortality of sepsis may be decreasing and, because there are more survivors, it is increasingly important to understand the epidemiology, pathogenesis, genetics, prevention, and treatment of the impaired long-term outcomes of sepsis. Recent insights on the clearance of bacterial products during sepsis suggest new strategies for early intervention. Immune suppression/immune reprogramming to ...

OBJECTIVE To compare the relative effects of intrapartum antibiotic prophylaxis regimens on patterns of early-onset neonatal sepsis. METHODS We performed an historical cohort study of 17187 infants born at our center from September 1993 to February 2000. A risk-based strategy was employed prior to July 1996 and a screening-based strategy was utilized thereafter. Ampicillin was utilized prior ...

INTRODUCTION Neutrophil CD64 has been proposed as an early marker of sepsis. This study aims to evaluate the diagnostic utility of neutrophil CD64 for identification of early-onset sepsis in preterm neonates. METHODS The prospective study was conducted in a neonatal intensive care unit between November 2010 and June 2011. Preterm neonates in whom infection was suspected when they were <12 hou...

Bacteremia and sepsis, along with other serious bacterial infections (SBIs), are still significant causes of morbidity and mortality among children worldwide despite the use of modern antibiotics and evidence-based resuscitation guidelines and treatments.1 Sepsis in neonates is a significant contributor to morbidity and mortality. Based on the onset, neonatal sepsis is classified into two major...

BACKGROUND Morbid obesity increases the cost of care in critically ill patients. Sepsis is the leading cause of death in noncoronary intensive care units. Circulating cell-endothelial cell interactions in microcirculation are the rate-determining factors in any inflammation; obesity increases these interactions further. Adiponectin deficiency is implicated in increased cardiovascular risk in ob...

Despite continuing advances in intensive care medicine, severe sepsis and septic shock are currently among the most common causes of morbidity and mortality in intensive care. Moreover, the incidence of severe sepsis and septic shock has increased with ageing of the population over the past decade [1-3]. The Surviving Sepsis Campaign advocates early identification and intervention worldwide to ...

Background: Preeclampsia is one of the leading causes death for both mother and fetus. divided into two categories onset, preeclampsia that begins at gestational age below 34 weeks called early onset late after above weeks. In early-onset preeclampsia, there an imperfect remodeling maternal spiral arteries, resulting in abnormal uteroplacental perfusion, causing hypoxia acidosis neonates which ...

Overproduction of nitric oxide and activation of soluble guanylate cyclase (sGC) are important in sepsis-induced hypotension and hyporesponsiveness to vasoconstrictors. A time course of the expression and activity of sGC in a sepsis model [cecal ligation and puncture (CLP)] was evaluated in rats. Soluble GC alpha-1 and beta-1 subunit mRNA levels increased in the lungs, but not in the aorta. How...

objective(s) in the last few years, serum procalcitonin has been proposed as an early marker of infections in neonates, with varying results. in this study, we aimed to investigate the value of procalcitonin, and c- reactive protein in establishing the diagnosis of neonatal sepsis. materials and methods blood samples were collected at admission from 69 neonates with suspected infection (admitte...

Newborns’ bacterial infections due to group B Streptococcus (GBS) happen in two forms including early-onset disease or late-onset disease. In this paper, we report a case of early-onset GBS infection in a male infant. A 22-year-old primigravid woman delivers a term normal looking male infant. Nasal flaring, grunting, and poor feeding presented soon after birth. An empiric treatment wit...