Background: The possible impact of corneal thickness, curvature, and size on the measurement of endothelial cell density (ECD) has largely been ignored in the normal eye. The aim of this study was to investigate the possible impact of the main corneal parameters on the analysis of ECD values at the central, superior, and temporal parts of the corneal surface. Methods: All 75 participants (52 fe...

A new electron capture detector (ECD) for the Agilent 6890 Series gas chromatograph (GC) allows very sensitive detection of nitroaromatic compounds at low picogram levels with a linear response over three orders of magnitude. Analysis of Nitroaromatics and Nitro-Polycyclic Aromatic Hydrocarbons by Capillary Gas Chromatography with the Agilent 6890 Micro-ECD This application note describes the p...

Equine Cushing's disease (ECD) is a chronic progressive disease of the intermediate pituitary gland of older horses. Horses with Cushing's disease often have other health problems, such as laminitis, chronic infections, pseudolactation, and other issues. Diagnosis of ECD is usually based on clinical signs and endocrine tests. Medical management of affected horses is usually a long-term or lifel...

BACKGROUND Determining if a kidney from a marginal donor is likely to elicit a strong and specific immune response, leading to an increased risk of acute rejection, is of importance in renal transplantation. METHODS In this study, we analysed the effect of extended criteria donor (ECD) on the incidence of biopsy-proven acute rejection (BPAR) and the effect of immunological risk factors on gra...

In bottom-up proteomics, proteolytically derived peptides from proteins of interest are analyzed to provide sequence information for protein identification and characterization. Electron capture dissociation (ECD), which provides more random cleavages compared to "slow heating" techniques such as collisional activation, can result in greater sequence coverage for peptides and proteins. Most bot...

Background Collection of kidneys from extended criteria donors (ECD) with diagnosed brain-death forms a part of the collection program that increases the number of transplantations. Objective To compare the results of ECD with those of standard criteria donors (SCD). Methods In a retrospective analysis in a group of 156 kidney donors, we identified ECD donors. We detected the basic paramete...

Monitoring the environment with serine/threonine protein kinases is critical for growth and survival of Mycobacterium tuberculosis, a devastating human pathogen. Protein kinase B (PknB) is a transmembrane serine/threonine protein kinase that acts as an essential regulator of mycobacterial growth and division. The PknB extracellular domain (ECD) consists of four repeats homologous to penicillin-...

: Erdheim-Chester disease (ECD) is an uncommon non-Langerhans cell histiocytosis. Bilateral symmetric sclerosis of the long bones and possible multiorgan involvement are main presentations this disease. Histologically, lipid-laden foamy histiocytes positive immunochemically for CD68 (occasionally PS100) negative S100 CD1a in ECD. Herein, we describe case a 35-year-old man diagnosed with ECD per...

Although electron capture dissociation (ECD) offers many advantages for structural elucidation, a fundamental understanding of all possible processes following electron capture is necessary if ECD is to succeed in the characterization of unknowns. Many biologically active compounds have non-standard structures, e.g, N-alkylation, branching, cyclization, and ester linkages. Here we report ECD of...

Erdheim-Chester disease (ECD) is a rare type of non-Langerhans cell histiocytosis, with only 550 cases reported worldwide. ECD is characterized by diffuse histiocytic infiltration of multiorgans. The age of presentation of this disease is typically between 40 and 70 years. Bone disease is the most common symptom, as unique radiological findings of long bone sclerosis occur in 96% of cases. Furt...