OLIG2 (originally designated BHLHB1) encodes a transcription factor that contains the basic helix-loop-helix motif. Although expression of OLIG2 is normally restricted to neural tissues, overexpression of OLIG2 has been shown in patients with precursor T-cell lymphoblastic lymphoma/leukemia (pre-T LBL). In the current study, we found that overexpression of OLIG2 was not only found in oligodendr...

Insulin expression in the thymus has been implicated in regulating the negative selection of autoreactive T cells and in mediating the central immune tolerance towards pancreatic beta-cells. To further explore the function of this ectopic insulin expression, we knocked out the mouse Ins2 gene specifically in the Aire-expressing medullary thymic epithelial cells (mTECs), without affecting its ex...

The pharyngeal apparatus is a transient structure that gives rise to the thymus and the parathyroid glands and also contributes to the development of arteries and the cardiac outflow tract. A typical developmental disorder of the pharyngeal apparatus is the 22q11 deletion syndrome (22q11DS), for which Tbx1 is responsible. Here, we show that Ripply3 can modulate Tbx1 activity and plays a role in...

background: the value of serial measurement of serum ß subunit of human chorionic gonadotropin (ßhcg) and ultrasonography in the early diagnosis of ectopic pregnancy has well established. objective: the objective of this study was to explore the diagnostic value of raising level of serum ßhcg, single measurement of progesterone (p) and estradiol (e2) in early diagnosis of ectopic pregnancy. mat...

Spindle epithelial tumor with thymus like differentiation (SETTLE) is a very rare tumor arising either from ectopic thymus or remnants of branchial pouches that retain the potential to differentiate along the thymic line.[1]; Herein is reported a case of SETTLE in a 50-year-old man who presented with dessiminated intravascular coagulopathy. The subsequent work up revealed the presence of a medi...

Abnormal overexpression of CXCL13 is observed in many inflamed tissues and in particular in autoimmune diseases. Myasthenia gravis (MG) is a neuromuscular disease mainly mediated by anti-acetylcholine receptor autoantibodies. Thymic hyperplasia characterized by ectopic germinal centers (GCs) is a common feature in MG and is correlated with high levels of anti-AChR antibodies. We previously show...

background: ovarian pregnancy is a rare form of the non-tubal ectopic pregnancy. it ends with rupture before the end of the first trimester. one of the important risk factors for ovarian pregnancy is in the use of intra uterine devices (iud). case:  we report here one such uncommon case of ovarian ectopic pregnancy. our patient is a 30 years old multiparous woman with two previous cesarean sect...

background: bilateral ectopic pregnancy is a rare condition and is divided in two subgroups, primary and secondary, based on history of assisted reproductive technology. case presentation: a 30 year old primigravid woman with history of infertility and ovulation induction presented to a hospital in kashan in year 2013. she had vaginal bleeding, abdominal pain and ultrasound findings suggested e...