BACKGROUND Job's syndrome (hyper IgE syndrome) is a very rare primary immunodeficiency disease that has an annual approximate incidence of less than 1/1,000,000. This manuscript aims to provide education regarding diagnosis and management strategies of this syndrome worldwide. CASE REPORT A 6-year-old boy was seen at the clinic secondary to persistent pruritus interfering with sleep. At the a...

An 11-year-old non-atopic football player experienced an itchy, erythematous andvesicular eruption, initially localized to both shins, in close contact with football shin pads, after having used these two or three times a week during a 3-month period. In the following 2months, the eruption spread all over the body, including the face, when he continued to play football with a jersey garment und...

INTRODUCTION Eczematous reactions to type I allergy-inducing antigens are documented in a subgroup of patients with atopic eczema. Yet, the underlying immunological mechanisms are not well understood. MATERIAL AND METHODS To delineate the effect of native pollen grains on human skin of healthy and atopic individuals we performed patch tests (atopy patch test with native pollen grains, PPT). N...

ost primary care physicians see a large number of patients each year ith eczematous skin diseases. Although many of these patients have topic eczema, another extremely common cause of eczema is contact llergy. This subgroup of eczema patients is notably resistant to treatment nless the causative allergens can be identified and eliminated. It is stimated that allergic contact dermatitis (ACD) to...

Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to thei...

Food allergy may provoke flares of atopic dermatitis. The prevalence of food allergy in infants with atopic eczema (AE) may be estimated at 40%. Most of cases of food allergies concern young children (infants aged under one year), and affected by recur eczema under appropriate treatment. Cow’s milk, hen’ eggs and wheat’ flours are the main food allergens involved in food allergies associated wi...

Melanocytic nevi represent a widespread cutaneous finding. Nevertheless, the presence of mycosis fungoides and melanocytic nevi in the same location is an extremely rare event. We report the case of a patient affected by mycosis fungoides and treated with PUVA therapy, with complete remission of the disease. Eight years after therapy discontinuation, he presented epidermal scaling and an erythe...

Hydroxychloroquine (HXQ) sulphate is a synthetic antimalaria drug that is widely used in rheumatology due to its immunosuppressive properties. Delayed-type sensitization to this drug is rare. A 47-year-old woman diagnosed with HLA B27 ankylosing spondylitis was treated with HXQ for 22 days and had to discontinue the drug due to gastric intolerance. Five days later the patient developed erythema...