Histone methylation plays a crucial role in various biological and pathological processes including cancer development. In this study, we discovered that JARID2, an interacting component of Polycomb repressive complex-2 (PRC2) that catalyzes methylation of lysine 27 of histone H3 (H3K27), was involved in Transforming Growth Factor-beta (TGF-ß)-induced epithelial-mesenchymal transition (EMT) of ...

Sickle cell disease (SCD) and ß-thalassemia represent the most common hemoglobinopathies caused, respectively, by the alteration of structural features or deficient production of the ß-chain of the Hb molecule. Other hemoglobinopathies are characterized by different mutations in the α- or ß-globin genes and are associated with anemia and might require periodic or chronic blood transfusions. The...

Through the esterification of cellulose (Cell) with ethylenediaminetetraacetic dianhydride, acid-functionalized (Cell-EDTA) was conveniently obtained. Furtherly a novel and efficient Cell-EDTA-supported palladium catalyst (Pd@Cell-EDTA) easily prepared via coordination Cell-EDTA PdCl2. The as-prepared Pd@Cell-EDTA fully characterized by inductively coupled plasma atomic emission spectrometry, X...

The objectives of this investigation are the studies on the effect of copper ion on photolytic degradation of ethylenediaminetertraaceticacid (EDTA), the effect of EDTA on electrolytic recovery of copper as well as the introduction of a novel combined photolytic and electrolytic cell system for simultaneous recovery of copper and the degradation of EDTA.In this experimental study, ...

Type 1 diabetes mellitus results from a cell-mediated autoimmune attack against pancreatic ß-cells. Traditional treatments involve numerous daily insulin dosages/injections and rigorous glucose control. Many efforts toward the identification of ß-cell precursors have been made not only with the aim of understanding the physiology of islet regeneration, but also as an alternative way to produce ...

The colicin A lysis protein, Cal, is synthesized at the same time as colicin A by Escherichiu coli harbouring plasmid pColA after induction by mitomycin C. Its function in the induced bacteria involves the release of colicin A, quasi-lysis, the death of the producing cells and the activation of the outer membrane phospholipase A. We have found that these various functions are affected different...

Therapy in nuclear medicine practice has a long distinguished history. Nuclear medicine therapy is required to be highly specific and targeted, since it always involves administration of unsealed sources of radioactivity. Most therapy agents utilize ß-particle emissions for their ability to penetrate tissues. This deposition of energy in tissue by ß emitters results in cellular damage. Among th...