A simple filtration technique was developed to prepare large scale free-standing close-packed gold nanoparticle ultrathin films using metal hydroxide nanostrands as both barrier layer and sacrificial layer. As thin as 70 nm, centimeter scale robust free-standing gold nanoparticle thin film was obtained. The thickness of the films could be easily tuned by the filtration volumes. The electronic c...

Background: Proton-impact metallic nanoparticles, inducing low-energy electrons emission and characteristic X-rays termed as Coulomb nanoradiator effect (CNR), are known to produce therapeutic enhancement in proton treatment on experimental tumors. The purpose of this pilot study was to investigate the effect of CNR-based dose enhancement on tumor growth inhibition in an iron-oxide nanoparticle...

We demonstrate an entirely new method of nanoparticle chemical synthesis based on liquid droplet irradiation with ultralow (<0.1 eV) energy electrons. While nanoparticle formation via high energy radiolysis or transmission electron microscopy-based electron bombardment is well-understood, we have developed a source of electrons with energies close to thermal which leads to a number of important...

background: the electron contamination may reduce or even diminish the skin sparing property of the megavoltage beam. the detailed characteristics of contaminant electrons are presented for different field sizes and cases. materials and methods: the monte carlo code, mcnpx, has been used to simulate 18 mv photon beam from a varian linac-2300 accelerator. all dose measurements were carried out u...

Introduction: The aim of this study was to investigate the initial electron beam parameters for Monte Carlo model of 6MV photon beam produced by Siemens Oncor® linear accelerator.   Materials and Methods: In this study, the EGSnrc Monte Carlo user codes BEAMnrc and DOSXYZnrc were used. The beamnrc code were used for modelling of a 6 MV photon beam produced by...

  Introduction: In the present study, we investigated the role of gold-silica shell-core nanoparticle in megavoltage irradiation of MCF7 breast cancer cells.   Materials and Methods: gold-silicon oxide shell-core nanoparticles (NPs) were obtained by conjugation of gold nanoparticle with amine or thiol functionalized silica nanoparticles (AuN@SiO2 and AuS@SiO...

The study of beam transport is of central importance to the design and performance assessment of modern particle accelerators. In this paper, we benchmark two contemporary codes, DIMAD and BDSIM, the latter being a relatively new tracking code built within the framework of GEANT4. We consider both the 20 mrad and 2 mrad extraction lines of the 500 GeV International Linear Collider (ILC) and we ...

The study of beam transport is of central importance to the design and performance assessment of modern particle accelerators. In this work, we benchmark two contemporary codes DIMAD and BDSIM, the latter being a relatively new tracking code built within the framework of GEANT4. We consider both the 20 mrad and 2 mrad extraction lines of the International Linear Collider (ILC) and we perform tr...

One of the most relevant risks in breast intraoperative electron radiotherapy (IOERT) is the incorrect positioning of the shielding disc. If such a setup error occurs, the treatment zone could receive a nonuniform dose delivery, and a considerable part of the electron beam could hit - and irradiate - the patient's healthy tissue. However misalignment and tilt angle of the shielding disc can be ...

Metal fiducial markers are often implanted on the back of the eye before proton therapy to improve target localization and reduce patient setup errors. We aim to detect characteristic x-ray emissions from metal targets during proton therapy to verify the treatment range accuracy. Initially gold was chosen for its biocompatibility properties. Proton-induced x-ray emissions (PIXE) from a 15 mm di...