16 The activity of supragranular pyramidal neurons in the dorsolateral prefrontal cortex (DLPFC) 17 neurons is hypothesized to be a key contributor to the cellular basis of working memory in primates. 18 Therefore, the intrinsic membrane properties, a crucial determinant of a neuron's functional properties, are 19 important for the role of DLPFC pyramidal neurons in working memory. The present ...

The objective of this study was to establish a three-dimensional (3-D) in vitro model system of cardiac muscle for electrophysiological studies. Primary neonatal rat ventricular cells containing lower or higher fractions of cardiac myocytes were cultured on polymeric scaffolds in bioreactors to form regular or enriched cardiac muscle constructs, respectively. After 1 wk, all constructs containe...

Glutamatergic, cholinergic and GABAergic neurons contribute to the septohippocampal pathway and exhibit distinct electrophysiological properties: novel implications for hippocampal rhythmicity.

Central neurons are highly vulnerable to injury and have limited ability to regenerate. Therefore, transplantation of exogenous neuronal progenitor cells has been considered a potential therapy for the restoration of lost neurons and associated brain function. In a previous study, we found that when injected into rat brain following focal ischemia, cortical neuronal progenitor cells cultured fr...

BACKGROUND Hematopoietic progenitor cells (HPCs) can improve cardiac function after myocardial infarction. However, occurrence of arrhythmias is a potential limitation of cell therapy. In this study, we investigated the cardiac electrophysiological properties of ex vivo expanded HPCs, generated by beta-catenin gene transfer, after transcoronary delivery in a murine model of ischemia/reperfusion...

Previous research assessing the presence of enhanced tactile skills in early-blind (EB) population obtained conflicting results. Most of the studies relied on behavioral measures with which different mechanisms leading to the same outcome go unnoticed. Moreover, the scarce electrophysiological research that has been conducted focused exclusively on the processing of microgeometric properties. T...

Introduction In corrected transposition of the great arteries (CTGA), the presence of 2 atrioventricular nodes (twin AVNs), their Purkinje systems, and a specific conduction system (Mönckeberg sling) connecting them to each other has been demonstrated using histologic and electrophysiological techniques.. Twin AVNs can induce supraventricular tachycardia (SVT) as a preoperative, perioperative, ...

the dentate gyrus of hippocampus has long been considered as a focal point for studies on mechanisms responsible for the development of temporal lobe epilepsy (tle). change in intrinsic properties of dentate gyrus granule cells (gcs) has been considered as an important factor responsible in temporal lobe seizures. in this study, we evaluated the intrinsic properties of gcs, during acute phase o...

background: prevalence of electrophysiological abnormalities in patients with lumbosacral radiculopathy was evaluated. methods: a cross-sectional study was performed on 97 consecutive patients with the clinical diagnosis of lumbosacral radiculopathy. complete neurological examinations and standard electrophysiological evaluation was performed on the patients. results: patients under study had t...