background: this study aims to investigate the patterns of bioaccumulation and depuration of copper in the selected kidney and liver of capoeta fusca. methods: the fish were collected between september and november 2010 from a qanat in birjand. they were exposed to two types treatments with copper (0.25 and 0.75 mg/l) for a period of 41 days. the fish under study were exposed to the above-menti...

since it was first diagnosed in 1914 in marrakesh, schistosomiasis has been a public health problem in morocco for decades. a national control program launched in 1982 has led to a considerable reduction in the incidence and morbidity associated with the disease. consequently, the program has shifted from disease control to an elimination process launched in 1994. this process aimed to eliminat...

background: baits have become popular and effective formulations against urban insect pests. compared with re­sidual sprays toxic gel baits are used more and more frequently to control urban cockroach populations. the aim of this study was to investigate the usage of two commercially available fipronil and imidacloprid gel bait formulations against blattella germanica field infested in iran. me...

conclusions affordable new hcv treatment regimens are available in iran, providing an opportunity for hcv elimination. recommendations provided in this current national guideline can facilitate evidence-based management of hcv infection. results pegylated interferon alpha (pegifn), ribavirin (rbv), sofosbuvir (sof), ledipasvir (ldv) and daclatasvir (dcv) are currently available in iran. pre-tre...

Lymphatic filariasis (LF) has been targeted for global elimination by 2020. The primary tool for the program is mass drug administration (MDA) with antifilarial medications to reduce the source of microfilariae required for mosquito transmission of the parasite. This strategy requires high MDA compliance rates. Egypt initiated a national filariasis elimination program in 2000 that targeted appr...

Neonatal jaundice can be best understood as a balance between the production and elimination of bilirubin, with a multitude of factors and conditions affecting each of these processes. When an imbalance results because of an increase in circulating bilirubin (or the bilirubin load) to significantly high levels (severe hyperbilirubinemia), it may cause permanent neurologic sequelae (kernicterus)...

Materials and methods Presented data come from 200 cases. Detoxification followed through 4 stages: long-acting benzodiazepine substitution, dose reduction, elimination, post-withdrawal observation. Clinical state (CIWA-B, [1]) and the benzodiazepine serum level (standard immunoenzymatic assay) were monitored. Patient’s dose reduction rate was adjusted according to current intensity of withdraw...

Ten male volunteers were exposed to ethylene glycol monoethyl ether acetate (EGEE-Ac) under various conditions of exposure and physical workload. As exposure proceeded, retention, atmospheric clearance, and uptake rate declined slowly to reach steady state levels after three to four hours. Retention increased as a consequence of higher exposure concentrations and of physical workload performed ...

An exploratory population pharmacokinetic model for functional dupilumab was developed. Data from healthy volunteers and patients with atopic dermatitis (AD) receiving intravenous or subcutaneous doses were integrated. The data included 197 participants (2,518 measurements of dupilumab in serum) from six phase I and II studies. The data were analyzed using stochastic approximation expectation-m...