A non-pigmented strain of Serratia marcescens was isolated ante-mortem and at post-mortem from the blood of six dogs under intensive medical care. Clinical, bacteriological and pathological evidence confirmed death to be associated with septicaemia from this Gram-negative organism. I N T R O D U C T I O N Serratia marcescens has been known to exist in both pigmented and non-pigmented varieties ...

Is response selection a unitary central cognitive mechanism? Some information processing theories assume it is (Pashler, 1994; Welford, 1959); whereas others suggest it may not be (Meyer & Kieras, 1997). This question was addressed by two studies using functional magnetic resonance imaging (fMRI) published in this issue of the Journal of Cognitive Neuroscience. Schumacher, Elston, and D’Esposit...

Although the syndrome of an exogenous lipoid pneumonia due to aspirated liquid paraffin has been established for some four decades, it is evident from many of the published reports, mainly in the American literature, that the diag-nosis is still frequently being missed unless investigations are deliberately undertaken with this possibility in mind. Rewell (1947) published the -first probable ca...

Desmopressin (DDAVP) is a vasopressin peptide analog with hemostatic properties that has been successfully used during surgery in patients with bleeding disorders. Recently published experimental and clinical data indicate that perioperative administration of DDAVP can minimize spread and survival of residual mammary cancer cells. The central aim of this study was to explore the effect of perio...

Reading disability (RD), or dyslexia, is a common heterogeneous syndrome with a large genetic component. Several studies have consistently found evidence for a quantitative-trait locus (QTL) within the 17 Mb (14.9 cM) that span D6S109 and D6S291 on chromosome 6p21.3-22. To characterize further linkage to the QTL, to define more accurately the location and the effect size, and to identify a peak...

Central serotonin dysfunction appears to be related to a subtype of alcoholism with antisocial impulsive features (type II; antisocial alcoholism). The serotonergic deficit may be associated with greater impulsivity, which in turn facilitates both alcohol dependence and antisocial behavior. The present study tested association of antisocial impulsive alcoholism with candidate genes related to s...

We propose a new method, G-REMLadp, to estimate the phenotypic variance explained by parent-of-origin effects (POEs) across the genome. Our method uses restricted maximum likelihood analysis of genome-wide genetic relatedness matrices based on individuals' phased genotypes. Genome-wide SNP data from parent child duos or trios is required to obtain relatedness matrices indexing the parental orig...

BACKGROUND Genome-wide association studies have identified polymorphisms associated with breast cancer subtypes and across multiple population subgroups; however, few studies to date have applied linkage analysis to other population groups. METHODS We performed the first genome-wide breast cancer linkage analysis in 106 African American families (comprising 179 affected and 79 unaffected memb...

Linkage- and association-based methods have been proposed for mapping disease-causing rare variants. Based on the family information provided in the Genetic Analysis Workshop 17 data set, we formulate a two-pronged approach that combines both methods. Using the identity-by-descent information provided for eight extended pedigrees (n = 697) and the simulated quantitative trait Q1, we explore var...

BACKGROUND We recently reported that DNA content of breast adenocarcinomas, cytometrically assessed by diploid (D), tetraploid (T), and aneuploid (A) categories, can be further divided into genomically stable and unstable subtypes by means of the stemline scatter index (SSI). The aim of the present study was to survey the clinical correlates and the prognostic value of the SSI in a consecutive ...