Novel drug delivery systems for controlled-release of opioid agonists as a long time painkillers or opioid antagonists for opium, heroin, and alcohol addiction are under development or in clinical use today. In this article, the field of “new drug delivery systems” is momentarily reviewed from the viewpoint of the marketed opioid agonists/antagonists dosage forms today.

for prolonging the time that drug remains in stomach, new methods used as floating drug delivery systems, that available in various forms such as floating tablets. these systems enhance drug absorption and decrease plasma concentration fluctuations. iron deficiency and its inadequate absorption in diet are of community health problems. for prolonging the time that drug remains in stomach, new m...

Self-emulsifying compositions are the basis of oral drug delivery systems used to improve solubility and increase bioavailability active pharmaceutical ingredients that poorly soluble in aqueous medium gastric juice. Aim. To develop self-emulsifying using simvastatin as an ingredient. Materials methods. During development composition mixture, excipients, such solvents, co-solvents, surfactants ...

microspheres formulated from poly (d,l-lactic-co-glycolide) (plga), a biodegradable polymer, have been extensively evaluated as a drug delivery system. in this study, the preparation, characterization and drug release properties of the plga microspheres were evaluated. simvastatin (sim)-loaded plga microspheres were prepared by oil-in-water emulsion/solvent evaporation method. the microspheres ...

Self-emulsifying drug delivery system (SEDDS), a type of lipid-based technology which are isotropic mixtures oil, surfactant, solvent, and co-solvents generated by the activity liquid or solid self-emulsifying ingredients onto powders. It shown interest in recently for enhancement solubility bioavailability poorly water-soluble drugs (BCS-II). With novelty research this field, novel Excipients ...

BACKGROUND As a poorly water-soluble drug, the oral application of morin is limited by its low oral bioavailability. In this study, a new self-nanoemulsifying drug delivery system (SNEDDS), based on the phospholipid complex technique, was developed to improve the oral bioavailability of morin. METHODS Morin-phospholipid complex (MPC) was prepared by a solvent evaporation method and characteri...

INTRODUCTION Compritol® 888 ATO is a lipid excipient that is generally used in cosmetic industry as a surfactant, emulsifying agent and viscosity-inducing agent in emulsions or creams. Based on its chemical composition, Compritol 888 ATO is a blend of different esters of behenic acid with glycerol. AREAS COVERED Recently, there has been great interest in the multiple roles that Compritol 888 ...

Purpose: Ofloxacin is a fluoroquinolone with broad-spectrum antibacterial action, used in treatment of systemic and local infections. Ofloxacin is BCS class II drug having low solubility, high permeability with short half-life. The present work was aimed to design, develop and optimize gellified emulsion of Ofloxacin to provide site targeted drug delivery. Transdermal drug delivery will enhance...