Supercritical fluids extraction of emulsions (SEE) is an innovative technique used for the production of micro, nano-particles with controlled size and distribution. Supercritical carbon dioxide (SC-CO2) is used to extract selectively the organic solvents from the droplets of the emulsion, in which the biopolymer is dissolved, producing the precipitation of the polymer and the subsequent format...

The objective of this study was to use Box-Behnken design (BBD) to investigate the influence of formulation variables on the properties of heparin-loaded poly(lactic-coglycolic acid) (PLGA)-polymethacrylate-RLPO (E-RLPO) nanoparticles (NP) in terms of mean diameter (as size) and drug encapsulation efficiency. The NPs were prepared by the double emulsion solvent evaporation method. The independe...

In this study, the effect of zinc on insulin stability during the primary emulsification step of poly(lactide-co-glycolide) microspheres preparation by the water-in-oil-in-water (w/o/w) double emulsion solvent evaporation technique was evaluated. Insulin was emulsified at homogenization speeds of 5000 and 10,000 rpm. Insulin was extracted from the primary w/o emulsion by a method previously rep...

We report a simple and convenient method for fabricating ordered porous structure in a polymeric thin film. A temporarily stabilized water-in-oil emulsion, where aqueous droplets were dispersed in the medium of polymer-organic solvent solution, was utilized for the preparation of porous structure. The water-in-oil emulsion was simply prepared by sonicating the mixture of water and polymer-organ...

objective:platycladus orientalis or thuja orientalis is a native plant of iran different parts of which are used in the treatment of various diseases such as: gout, rheumatoid arthritis, common cold, cough, bronchitis, asthma, high blood pressure and hormonal disorders like hirsutism and baldness. also, various organs of this species have been used as appetizer. the purpose of this study was to...

The objective of this investigation was to develop the hollow microspheres as a new dosage form of floating drug delivery system with prolonged stomach retention time. Hollow microspheres containing ranitidine hydrochloride were prepared by solvent evaporation method using Eudragit RLPO dissolved in a mixture of dichloromethane and ethanol. The maximum yield and drug loading amount of hollow mi...

The aim of our studies was to formulate a system that delivers the required radiation dose to the tumor site and minimize the harm to other organs or tissues. The poly (lactic-co-glycolic acid, 75:25; 50:50) microspheric radiation delivery system was fabricated using double emulsion solvent evaporation technique for the encapsulation of technetium-99m(V)dimercaptosuccinic acid ((99m)Tc(V)DMSA)....