نتایج جستجو برای: endocannabinoid signaling
تعداد نتایج: 301155 فیلتر نتایج به سال:
Earlier results from our laboratory demonstrated that the mechanism by which both endoand exogenous cannabinoids interfer with network oscillations and associated cognitive functions is through the reduction of basket cell-mediated GABAergic inhibition and glutamatergic excitation in the cerebral cortex via presynaptic CB1 cannabinoid receptors. Combined molecular anatomy and electrophysiology ...
Marijuana exerts profound effects on human social behavior, but the neural substrates underlying such effects are unknown. Here we report that social contact increases, whereas isolation decreases, the mobilization of the endogenous marijuana-like neurotransmitter, anandamide, in the mouse nucleus accumbens (NAc), a brain structure that regulates motivated behavior. Pharmacological and genetic ...
Anxiety disorders peak in incidence during adolescence, a developmental window that is marked by dynamic changes in gene expression, endocannabinoid signaling, and frontolimbic circuitry. We tested whether genetic alterations in endocannabinoid signaling related to a common polymorphism in fatty acid amide hydrolase (FAAH), which alters endocannabinoid anandamide (AEA) levels, would impact the ...
Endocannabinoid signaling couples activity-dependent rises in postsynaptic Ca2+ levels to decreased presynaptic GABA release. Here, we present evidence from paired recording experiments that cannabinoid-mediated inhibition of GABA release depends on the firing rates of the presynaptic interneurons. Low-frequency action potentials in post hoc identified cholecystokinin-positive CA1 basket cells ...
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