The study was designed with an aim to evaluate the antiperoxidative potential of ascorbic acid on busulfan-induced lipid peroxidation. The study was performed in vitro using goat liver as lipid source. This evaluation was done by measuring the 4-hydroxy-2-nonenal (4-HNE) and nitric oxide (NO) content of liver tissue homogenates as markers of lipid peroxidation. The study reveals the lipid perox...

BACKGROUND: Antioxidant molecules, which scavenge free radical species to prevent or delay oxidative damage of important macromolecules, membrane lipids and lipoproteins, are prevalent in plasma and other biological fluids. Among them, bilirubin, uric acid and protein thiols are the major endogenous antioxidants, while vitamins C and E, as well as a number of food-derived (poly)aromatic substan...

The present study was designed to investigate the cardio protective role of chronic oral administration of alcoholic extract of Terminalia arjuna in in-vivo ischemic reperfusion injury and the induction of HSP72. Rabbits, divided into three groups, and were administered with the alcoholic extract of the bark powder of Terminalia arjuna (TAAE) by oral gavage [6.75mg/kg: (T1) and 9.75mg/kg: (T2),...

The concept of oxidative stress (OS) was originally used by Professor Helmut Sies who described it as “an imbalance between oxidants and antioxidants in favor of the oxidants, potentially leading to damage” with the ratio of oxidants to antioxidants as >1 (Sies, 1997). Oxidative/nitrosative stress represents the bodies’ imbalance in the production and the elimination of reactive oxygen and nitr...

Lipid oxidation is one of the major quality issues wholegrain wheat flour and products, despite their rich endogenous antioxidants. Diverse germplasm resources are available for industrial production breeding selection. Therefore, to improve stability qualities wholegrain, it important study lipid varieties, together with antioxidant contents. In this study, 65 varieties were evaluated oxidativ...

BACKGROUND Malvidin (alvidin-3-glucoside) is a polyphenol that belongs to the class of natural anthocyanin, which is abundantly found in red wines, colored fruits, and the skin of red grapes. Therefore, the current investigation was intended to evaluate the effect of malvidin against myocardial infarction induced by isoproterenol in the rats. MATERIAL AND METHODS The cardioprotective effects wa...

The current study dealt with the protective role of garlic oil on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Subcutaneous injection of ISO (20 mg/kg body weight in1ml saline) to rats for 2 consecutive days offered significant alteration in biochemical parameters and moderate necrosis in heart. Effect of garlic oil oral treatment for 60 days (75 mg /kg body weight) was evalu...

BACKGROUND Oxidative stress plays a major role in the biochemical and pathological changes associated with myocardial ischemic-reperfusion injury (IRI). The need to identify agents with a potential for preventing such damage has assumed great importance. Chronic oral administration of raw garlic has been previously reported to augment myocardial endogenous antioxidants. In the present study, th...

There is a wealth of epidemiological information on antioxidants and their possible prevention of disease progression but very little of the research on antioxidants has involved intervention studies. In this study, the potential protective effect of vitamin C or E supplementation in vivo against endogenous and H2O2-induced DNA damage levels in lymphocytes was assessed. The supplementation invo...

Oxidative stress including DNA damage, increased lipid and protein oxidation, are important features of aging and neurodegeneration suggesting that endogenous antioxidant protective pathways are inadequate or overwhelmed. Importantly, oxidative protein damage contributes to age-dependent accumulation of dysfunctional mitochondria or protein aggregates. In addition, environmental toxins such as ...