نتایج جستجو برای: endometrial cancer
تعداد نتایج: 924649 فیلتر نتایج به سال:
Endometrial cancer is one of the most common gynecologic malignancies. Phosphatase and tensin homologue (PTEN)-mutation is frequently identified in endometrial cancer patients. Although high dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) has been associated with reduced risk of endometrial cancer, the underlying mechanisms is still unknown. To this end, we evaluated the impact of ω-3...
Data on the role of dietary factors in endometrial cancer development are limited and inconsistent. We applied a "nutrient-wide association study" approach to systematically evaluate dietary risk associations for endometrial cancer while controlling for multiple hypothesis tests using the false discovery rate (FDR) and validating the results in an independent cohort. We evaluated endometrial ca...
Recent large--scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also ass...
Endometrial cancer is the most common female genital tract cancer in the United States. The majority of cases are confined to the uterus. Treatment of organ-confined uterine cancer usually comprises total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH/BSO). In 1988, clinical staging of endometrial cancer was replaced with surgical staging because of inaccuracies associated with...
BACKGROUND Metabolic syndrome and its component feature, central obesity, are associated with endometrial cancer risk. It remains unclear whether associations with the other metabolic factors that comprise metabolic syndrome are independent of the obesity-endometrial cancer association. Furthermore, the link with specific endometrial cancer subtypes remains ill-defined, despite evidence of etio...
OBJECTIVE This study was undertaken to identify and quantify risk factors for endometrial cancer among young women. STUDY DESIGN This case-control study included all Danish women <50 years old who had endometrial cancer diagnosed during the period 1987 to 1994. A total of 237 case patients and 538 population control subjects matched with the case patients for age and residence were included i...
BACKGROUND The increase in the worldwide incidence of endometrial cancer relates to rising obesity, falling fertility, and the ageing of the population. Transvaginal ultrasound (TVS) is a possible screening test, but there have been no large-scale studies. We report the performance of TVS screening in a large cohort. METHODS We did a nested case-control study of postmenopausal women who under...
Endometrial cancer is the most common gynecologic cancer in the United States and the fourth most common cancer in women. Although endometrial cancer most often presents at an early stage, when surgical treatment is effective, chemotherapy has become a critical component in the treatment of advanced or recurrent endometrial cancer. The use of chemotherapy has evolved and is now often administer...
The Role of Chest Computed Tomography in the Work-up of Patients with Cervical or Endometrial Cancer
Background and Objectives: To determine whether chest CT-scan in patients with cervical or endometrial cancer is of additional value for planning initial treatment and work-up. Methods: A retrospective analysis was performed of 465 patients diagnosed with cervical or endometrial cancer between January 2003 and December 2007. All patients who underwent a chest CT-scan before treatment were inclu...
Cancer invasion is an outcome of interactions of the cancer and the host cell. It is now becoming increasingly clear that ovarian hormones have a huge influence on such intercommunications in various types of cancers. Estrogen is known to aggravate the aggressiveness of the endometrial cancer whereas progesterone seems to act as a negative factor. Insight into the mode of ovarian hormonal actio...
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