Lipolysis-stimulated lipoprotein receptor (LSR) has been identified as a novel molecular constituent of tricellular contacts that have a barrier function for the cellular sheet. LSR recruits tricellulin (TRIC), which is the first molecular component of tricellular tight junctions. Knockdown of LSR increases cell motility and invasion of certain cancer cells. However, the behavior and the roles ...

Previous studies have demonstrated that some human endometrial carcinomas contain an activating point mutation in codon 12 of the Ki-ras protooncogene. To examine the hypothesis that this mutation may occur at an earlier stage of neoplastic progression in the endometrium, we analyzed 89 samples of premalignant endometrial hyperplasia and an additional 84 samples of endometrial carcinoma for poi...

The effect of Shoutai pill on endometrial receptivity was analyzed. A total of 160 patients with spontaneous abortion were enrolled in this study. They were treated in the Fifth People's Hospital of Jinan (Shandong, China) from February 2014 to June 2016. The following treatment regimen was performed for the patients: after menstruation, Shoutai pill was taken as continuous medication for more ...

p16 is a negative regulator of cell proliferation and is considered a tumor suppressor protein. Alterations in p16 protein expression are associated with tumor development and progression. However, the p16 expression status in the peritumoral stroma has not been investigated in the endometrium. Therefore, we evaluated stromal p16 expression in different types of endometrial lesions using immuno...

Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. An imbalance caused by increased E2 action and/or decreased P4 action can result in abnormal endometrial proliferation and, ultimately, endometrial adenocarcinoma, the fourth most common cancer in women. We have identified mitogen-inducible gene 6 (Mig-6) as a downstream target of progesterone recepto...

The expression of interstitial collagenase-1 in the cycling human endometrium is restricted to the perimenstrual phase and is a key event for matrix degradation that initiates menstruation. In the absence of ovarian steroids, collagenase production by endometrial fibroblasts is induced by epithelial cell-derived interleukin-1alpha. Media conditioned by endometrial epithelial cells were found to...

Dysfunctional uterine bleeding (DUB) is defined as heavy and or irregular menstruation in the absence of recognizable pelvic pathology, pregnancy or general bleeding disorder. Hyperplastic endometrium is abnormal histology finding found in DUB. Out of three type of hyperplasia, atypical type is associated with co-existent ca endometrium and the chance of progression to ca endometrium is very hi...

INTRODUCTION Human epidermal growth factor receptor (HER)-2 overexpression or gene amplification is more common in high-grade or type 2 endometrial carcinomas. We assessed the discordance of HER-2 expression between primary and metastatic or recurrent endometrial carcinomas. MATERIALS AND METHODS Thirty-six primary, along with 14 metastatic and five recurrent tumors (matched to primaries), pa...

objective: in order to evaluate the endometrium by ultrasound in patients undergoing controlled ovarian hyperstimulation (coh) with clomiphene citrate (cc) and human menopausal gonadotropin (hmg) with intrauterine insemination (iui) to determine the relationship between endometrial pattern and thickness on pregnancy rate (pr). methods: in this prospective study, 108 infertile couples underwent ...

Endometrial cancer is the fourth most common cancer affecting British women, behind breast, lung and colon cancer. Over the past 20 years, the incidence of endometrial cancer has risen by 40%, and deaths by 20%, despite improved overall survival rates. Currently more than 1900 British women die from endometrial cancer each year, compared with fewer than 1500 at the turn of the century. The agin...