ERGIC-53 (former designation, p53) is a 53-kDa nonglycosylated, dimeric, and hexameric type I membrane protein that has been established as a marker protein for a tubulovesicular intermediate compartment in which protein transport from the endoplasmic reticulum to the Golgi apparatus is blocked at 15 degrees C. Although ERGIC-53 is not a resident protein of the rough endoplasmic reticulum its c...

The aberrant accumulation of toxic protein aggregates is a key feature of many neurodegenerative diseases, including Huntington's disease, amyotrophic lateral sclerosis and Alzheimer's disease. As such, improving normal proteostatic mechanisms is an active target for biomedical research. Although they share common pathological features, protein aggregates form in different subcellular locations...

Rough endoplasmic reticulum, Golgi apparatus, and plasma membrane rich cell fractions were isolated from livers of rats under similar conditions of age and diet for analysis of phospholipid classes and fatty acid composition. Phosphatidylcholine was the major phospholipid of all membrane types. Golgi apparatus was intermediate between endoplasmic reticulum and plasma membrane with respect to le...

The cytodifferentiation and subcellular steroidogenic sites in the granulosa cell of the developing follicle and in vitro effect of estradiol-17 ~ (E2) on the granulosa cell of the preovulatory follicle in the human ovary were investigated using the electron microscopic cytochemistry. The follicular cell in the primordial follicle showed an elongated nucleus, rough endoplasmic reticulum, Golgi ...