Oxygen- and nitrogen-derived free radicals and oxidants play an important role in the pathogenesis of diabetic endothelial dysfunction. Recently we proposed the importance of oxidant-induced DNA strand breakage and activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) in the pathogenesis of diabetic endothelial dysfunction. In this study, we tested whether established diabetic end...

This article relates the current pathophysiologic and radiologic findings to fundamental idea of acute lung epithelial infection, alveolar inflammation causing leak into interstitial space, subsequent secondary or concurrent endothelial infection dysfunction. Understanding mechanisms timings damage can better inform types ventilatory support required timing targeted pharmacotherapies.

Background Evidence suggests that microvascular function may be compromised in Peripheral Arterial Disease (PAD) due to associated endothelial dysfunction. While revascularization is recommended for PAD patients with macrovascular occlusions, a solution for endothelial dysfunction remains unavailable. For a possible endothelium-targeted therapy to be applied, the burden of endothelial dysfuncti...

During the experiment, modeling of endothelial dysfunction male rats was performed by intraperitoneal administration L-NAME at a dose 25 mg/kg for 7 days, and same female bilateral ovarioectomy further 7. The deficiency nitric oxide as result NO-synthase blockade accompanied impairment endotheliumdependent independent vasodilatation estimated in pharmacological tests, which expressed increasing...

Endothelial dysfunction is a well established response to cardiovascular risk factors and precedes the development of atherosclerosis. Endothelial dysfunction is involved in lesion formation by the promotion of both the early and late mechanisms of atherosclerosis including up-regulation of adhesion molecules, increased chemokine secretion and leukocyte adherence, increased cell permeability, e...

AIMS Endothelial dysfunction is an early step in the development of atherosclerosis. Increased formation of superoxide anions by NADPH oxidase Nox1, 2, and 5 reduces nitric oxide availability and can promote endothelial dysfunction. In contrast, recent evidence supports a vasoprotective role of H2O2 produced by main endothelial isoform Nox4. Therefore, we analysed the impact of genetic deletion...