نتایج جستجو برای: endothelioma
تعداد نتایج: 221 فیلتر نتایج به سال:
The antiangiogenic activity and antitumor efficacy of a newly developed matrix metalloproteinase (MMP) inhibitor were examined. N-biphenyl sulfonyl-phenylalanine hydroxiamic acid (BPHA) potently inhibits MMP-2, -9, and -14, but not MMP-1, -3, or -7. In contrast, (-)BPHA, an enantiomer of BPHA, was inactive against all MMPs tested. Daily oral administration of 200 mg/kg BPHA, but not (-)BPHA in ...
The enhancement of tumor metastasis by concurrent inflammatory processes is mainly due to the cytokines TNF and IL-1. In the case of TNF this effect is not restricted to metastasis models as measured by in vivo colony formation but also found in experimental model systems of spontaneous metastasis. Direct effects on the tumor cells or interference with the host NK cell system did not seem to ac...
Vaginal metastases from hypernephroma are rare. A review of the literature reveals only 16 such cases. Yet in the last twenty-eight months we have seen 4 cases. Lubarsch, in mentioning the various probable sites of metastasis in hypernephroma, includes the vagina as a rare location, though he believes that this form of metastasis is more common than is generally supposed, many cases appearing i...
Hepatic epithelioid hemangio endothelioma (HEHE) is a rare tumor of the liver, vascular in origin. Orthotopic liver transplantation (OLT) is the accepted treatment option for bilobar infiltrating tumors. In case of limited and stable extrahepatic invasion, OLT is not strictly contraindicated. This study presents two HEHE cases treated with living donor liver transplantation (LDLT). The first pa...
Targeting olfactomedin-like 3 inhibits tumor growth by impairing angiogenesis and pericyte coverage.
Antiangiogenic drugs have been used as anticancer agents to target tumor endothelial cells or pericytes. Because of limited efficacy of the current monotherapies, there is a strong demand for the dual targeting of endothelial cells and pericytes. Here, we identify Olfactomedin-like 3 (Olfml3) as a novel proangiogenic cue within the tumor microenvironment. Tumor-derived Olfml3 is produced by bot...
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