Purpose of the Work. The objective of this study was to determine energy expenditure and fat-free mass (FFM), as well as the relationships between these parameters, in persons with spinal cord injury (SCI). Subjects and Procedures. Thirteen pairs of monozygotic twins discordant for SCI were studied. Basal energy expenditure (BEE) and resting energy expenditure (REE) were determined by indirect ...

1. Resting energy expenditure was measured, by indirect calorimetry, in 12 patients with Parkinson's disease and in eight healthy age-matched control subjects. In the patients with Parkinson's disease measurements were made in both the untreated state and after an injection of the dopamine agonist apomorphine (treated state). In each state muscle rigidity was recorded. 2. Resting energy expendi...

Obesity occurs when energy intake exceeds energy expenditure over a protracted period of time. The energy expenditure associated with everyday activity is called NEAT (Nonexercise activity thermogenesis). NEAT varies between two people of similar size by 2000 kcal day(-1) because of people's different occupations and leisure-time activities. Data support the central hypothesis that NEAT is pivo...

The relationship between exercise and energy expenditure is unclear, with some suggestions that exercise leads to increased energy expenditure over and beyond the increase due to the exercise itself. In this cross-sectional study, we examined the relationships among aerobic fitness level, body composition, and total daily energy expenditure in 78 subjects. Daily energy expenditure (determined i...

Neural regulation of energy expenditure is incompletely understood. By genetically disrupting GABAergic transmission in a cell-specific fashion, and by combining this with selective pharmacogenetic activation and optogenetic mapping techniques, we have uncovered an arcuate-based circuit that selectively drives energy expenditure. Specifically, mice lacking synaptic GABA release from RIP-Cre neu...

OBJECTIVE Use comparison with indirect calorimetry to confirm the ability of our previously described equation to predict resting energy expenditure in mechanically ventilated patients. DESIGN Prospective, validation study. SETTING Eighteen-bed, medical intensive care unit at a teaching hospital. PATIENTS All adult patients intubated >24 hrs were assessed for eligibility. Exclusion criter...

Knowledge of whole-body energy expenditure is important if we are to make accurate estimates of energy requirements for optimum health and performance in man and optimum health, performance and production in animals. Energy requirements vary with nutritional, genetic and environmental influences and these can interact in complex ways, therefore it is necessary to isolate and identify specific f...

The CB1 receptor antagonist, rimonabant, affects the endocannabinoid system and causes a sustained reduction in body weight (BW) despite the transient nature of the reduction in food intake. Therefore, in a multiple-dose study, female candy-fed Wistar rats were treated with rimonabant (10 mg/kg) and matched with pair-fed rats to distinguish between hypophagic action and hypothesized effects on ...