OBJECTIVE The aim of this study was to evaluate possible interactions among Angiotensin-I converting enzyme genotype, insertion/deletion polymorphism and atherosclerosis of vein grafts in Iranian patients, and characterize their clinical and demographic profile. METHODS In this cross-sectional study, patients who underwent coronary artery bypass graft surgery more than five years ago, were in...

Background and Aims: Involvement of matrix metalloproteinases 3 (MMP3) in breast cancer tumor progression and metastasis has been revealed. MMP3 -1171 5A/6A and 5A/5A polymorphisms in the gene  promoter increase expression of the enzyme. The possible relationship of these polymorphisms and serum levels of major histocompatibility complex class I chain-related protein A and B (MICA/B) in br...

Apolipoprotein E (APOE) and oxidative damage were correlated with the risk of Alzheimer's disease (AD). Glutathione S-transferase (GST) polymorphism was proved to be associated with body antioxidant capacity and involved in the oxidative damage related chronic diseases. To explore the combined effects of APOE rs429358, rs7412 and GSTM1/T1 polymorphism on antioxidant parameters and cognition in ...

The renin-angiotensin system plays an important role in the pathogenesis of cardiovascular disease. Cloning of the human genes coding for the angiotensin-converting enzyme, angiotensinogen, and angiotensin II type 1 receptor has led to the discovery of several polymorphisms, which may be implicated in the pathogenesis of cardiovascular disease. The deletion/insertion (D/I) polymorphism of the a...

BACKGROUND AND AIMS Increased generation of reactive oxygen species and mitochondrial dysfunction may underlie the pathophysiology of Friedreich's ataxia, the most common inherited ataxia, due to GAA expansion in a gene coding for a mitochondrial protein (frataxin), implicated in the regulation of iron metabolism. Because iron overload would cause oxidative stress in Friedreich's ataxia, we inv...

interleukin-8 (il-8) is a well-known inflammatory chemokine and suggested to be involved in the development of acne vulgaris. this study investigates il-8 plasma levels in acne patients and healthy controls and the molecular basis for the regulation of the il-8 gene in a pakistani population.patients with acne vulgaris (n=264) and healthy individuals (n=264) were enrolled in this investigation....

background: ulcerative colitis (uc) is a multi-factorial autoimmune disease. p-glycoprotein is encoded by the multidrug resistance 1 (mdr1) gene. the c3435t polymorphism in the mdr1 gene is correlated with low p-glycoprotein expression. additionally, vitamin d has regulatory effects on the immune system. the aim of our study was to determine the association between the c3435t mdr1 polymorphism ...

avian influenza is a contagious viral disease affecting the respiratory, digestive and nervous system of birds belong to orthomyxovirus family. in the chicken mx gene, type of amino acid at position 631 determines the antiviral activity against influenza and vesicular stomatitis virus. a single nucleotide polymorphism (snp) at position 2032, responsible for the variation of amino acid at positi...