Epilepsy is a neurological condition that accompanies mankind probably since its inception. About 400 years before Christ, the disease was already known by Hippocrates, who wrote the book “On The Sacred Disease”, in which it refuted the idea that the upheaval was the work of spirits and wisely related to brain. This concept was not fully accepted until modern era (Horsey, 1886). Classically, ep...

Frontal lobe epilepsy (FLE) surgery is the second most likely pharmacoresistant focal epilepsy benefitting from surgical treatment secondary to temporal lobe epilepsy (TLE). This study aims to investigate the clinical characteristics of frontal lobe epilepsy and analyze the factors associated with the prognosis of surgery. 27 patients confirmed with frontal lobe epilepsy by surgery from 2010 to...

#### Notable in Neurology This Week issue features an article that explores the risk of cognitive deterioration children after epilepsy surgery; another investigates how sun and ultraviolet radiation exposure contribute to pediatric-onset multiple sclerosis. A featured Review examines physiologic clinical implications enlarged perivascular spaces aging brain. ### Epilepsy-Related Mortality Chil...

While medical treatment remains the first line of treatment for epilepsy, surgery provides effective long-term control in suitable patients. Detailed investigations are necessary to prove suitability and in order to choose the appropriate procedure. This article gives an outline of the investigative programme and the various operative approaches. Novel methods and those under investigation are ...

Background: The most common treatment modality for epileptic patients is antiepileptic drug (AED) therapy. However, more than 30% of epileptic patient suffers from drug-resistant epilepsy despite the use of appropriate AEDs. Surgery is a common option for these patients. Epilepsy surgery requires sophisticated medical technologies, many of them not available in Iran. The authors of the present ...

INTRODUCTION Epilepsy associated with tuberous sclerosis complex (TSC) is drug resistant in more than half of the patients. Epilepsy surgery may be an alternative treatment option, if the epileptogenic tuber can be identified reliably and if seizure reduction is not at the expense of cognitive or other functions. We report the pre-surgical identification of the epileptogenic tuber and post-surg...

Surgery is a valuable option for pharmacologically intractable epilepsy. However, significant post-operative improvements are not always attained. This is due in part to our incomplete understanding of the seizure generating (ictogenic) capabilities of brain networks. Here we introduce an in silico, model-based framework to study the effects of surgery within ictogenic brain networks. We find t...

This article covers the MRI evaluation of patients with epilepsy, with a focus on neuroimaging in those with localization-related epilepsy who may be potential epilepsy surgery candidates. The article includes structural MRI to identify a lesion, functional MRI to identify the eloquent cortex and diffusion tensor imaging to identify the eloquent white matter tracts. We consider the equipment, p...