Gynaecological epithelial tumours are commonly encountered in surgical pathology departments. Pathologists may have major problems in the interpretation of certain tumours. In this session, the emphasis is on the pitfalls in the diagnosis of premalignant and early invasive carcinomas of the vulva and cervix, together with the difficulty and confusion in the diagnosis of the endometrial hyperpla...

Since neoplasia has been induced in tissue culture by means of a chemical carcinogen (5), the question arises whether similar neoplastic transformation of cells in vitro can be brought about by other types of carcinogens, such as viruses. This question was answered by successfully growing epidermis of the domestic rabbit in tissue culture and then inoculating it with the Shope papilloma virus. ...

Chronic inflammation and cancer are closely associated in the intestine. Anti-inflammatory medication reduces intestinal neoplasia, while colorectal cancer incidence is increased in ulcerative colitis. Cyclooxygenases are key to both diseases, yet the molecular basis of the association remains incompletely understood. Two recent Cell (Greten et al., 2004; Rakoff-Nahoum et al., 2004) papers illu...

Carcinosarcoma is a rare biphasic neoplasia containing both malignant mesenchymal and epithelial elements. Bladder carcinosarcoma commonly presented as high-grade, advanced stage, and aggressive behavior with a poor prognosis. An 83-year-old male presented with painless gross hematuria to our hospital. Cystoscopy revealed massive nonpapillary bladder tumor on the right wall. The 91 g tumor coul...

Epithelial mesenchymal transition has been postulated as a versatile mechanism which facilitates cellular repositioning and redeployment during embryonic development, tissue reconstruction after injury, carcinogenesis, and tumor metastasis. The hypothesis originates from parallels drawn between the morphology and behavior of locomotory and sedentary cells in vitro and in various normal and path...

Healing of cervical epithelium was studied in 30 patients after destruction of cervical intraepithelial neoplasia using a carbon dioxide laser. Repeated examinations, using photography and colposcopically directed punch biopsies, were made from the eighth to the 32nd day after treatment. The biopsy specimens were submitted to examination by light and transmission electron microscopy. There was ...

Loss of polarity correlates with progression of epithelial cancers, but how plasma membrane misorganization drives oncogenic transcriptional events remains unclear. The polarity regulators of the Drosophila Scribble (Scrib) module are potent tumor suppressors and provide a model for mechanistic investigation. RNA profiling of Scrib mutant tumors reveals multiple signatures of neoplasia, includi...

Colon epithelial cells express and most colon cancers overexpress M3 muscarinic receptors (M3R). In human colon cancer cells, post-M3R signaling stimulates proliferation. To explore the importance of M3R expression in vivo , we used the azoxymethane-induced colon neoplasia model. Mice treated with weekly i.p. injection of saline [10 wild-type (WT) mice] or azoxymethane (22 WT and 16 M3R / mice)...

Papillomaviruses have evolved over many millions of years to propagate themselves at specific epithelial niches in a range of different host species. This has led to the great diversity of papillomaviruses that now exist, and to the appearance of distinct strategies for epithelial persistence. Many papillomaviruses minimise the risk of immune clearance by causing chronic asymptomatic infections...

Erratum The original version of this article [1] unfortunately contained incorrect figure files. Figures 4 and 7 in main body which have been replaced with new version of these figures. The corrected Figures include 3 added HE (a,b,c) and total 15 (a-o) figures, each. The new version of these files are included below. Furthermore, Additional File 1 has been updated to remove Fig. 3 and 6 which ...