Brucine diol (BD) catalyzed asymmetric Morita–Baylis–Hillman (MBH) reaction is observed for the first time. N-oxide (BNO) was found to not have an effective chiral catalyst. Faster rate obtained using unsaturated ester or aromatic aldehydes in presence of BNO. 4-Nitrobenzaldehyde and α,β-unsaturated ketone/ester were converted MBH adduct moderate yields (up 74%) with 70% ee value by this cataly...

Polymer networks with dynamic bonds, also known as covalent adaptable (CANs) combine the superior mechanical properties and chemical resistance of thermosets ability to be reprocessed, a feat formerly attributed only thermoplastics. Inspired by an evergrowing body research on poly(?-hydroxy ester) networks, polyacrylate/epoxy-acid thermoset was designed, which contains high concentration ?-hydr...

This study reports on the synthesis of zinc oxide (ZnO) nanostructures and examines the performance of polymer nanocomposites fabricated using ZnO dispersed in polymer host matrices. The polymer matrix used was an epoxy based thermosetting polymer known as Diglycidyl Ether of Bisphenol-A(DGEBA). Zinc oxide nano particles were prepared by precipitation method using Poly Vinyl Alcohol as the surf...

This study reports on the synthesis of zinc oxide (ZnO) nanostructures and examines the performance of polymer nanocomposites fabricated using ZnO dispersed in polymer host matrices. The polymer matrix used was an epoxy based thermosetting polymer known as Diglycidyl Ether of Bisphenol-A(DGEBA). Zinc oxide nano particles were prepared by precipitation method using Poly Vinyl Alcohol as the surf...

A high yielding rearrangement of epoxy-esters, under Lewis acid conditions, to give bicyclic ortho esters is reported.

Small-molecule microarrays composed of tens of thousands of distinct synthetic molecules, natural products, and their combinations/modifications provide a high-throughput platform for studying protein-ligand interactions. Immobilization of small molecule compounds on solid supports remains a challenge as widely varied small molecules generally lack unique chemical groups that readily react with...

Soluble epoxide hydrolase (sEH) is suggested to alter the mode of action and increase the toxic potency of fatty acid epoxides. To characterize the structural features necessary for sEH-dependent epoxy fatty acid toxicity, 75 aliphatic compounds were assayed for cytotoxicity in the presence and absence of sEH. Three groups of aliphatic epoxide-diol pairs were described by their observed differe...