High-molecular-weight DNA from cell line Raji (derived from Burkitt's lymphoma), which contains 50-60 copies of Epstein-Barr virus DNA per cell, was fractionated in neutral solution by several cycles of CsCl gradient centrifugation in fixed-angle rotors. Under the fractionation conditions used, intact Epstein-Barr virus DNA from virus particles can be separated from the less-dense cellular DNA....

(n = 4) were tested for serologic evidence of infection with 8 zoonotic pathogens.

14. Nonoyama, M.. and J. S. Pagano. 1971. Detection of Epstein-Barr viral genome in nonproductive cells. Nature (New Biol.) 233:103. 15. Nonoyama. M. 1975. Detection of tumor virus genomes by nucleic hybridization. Int. Rev. Exp. Pathol. 14:69. 16. Raab-Traub. N., T. Dambaugh. and E. Kieff. 1980. DNA of Epstein-Barr virus VIII. 895-8, the Prennis prototype, is an unusual deletion derivative. Ce...

OBJECTIVES To determine whether the Epstein-Barr virus is present in synovial membranes and subcutaneous nodules of patients with rheumatoid arthritis. METHODS A sensitive in situ hybridisation technique was applied to tissue sections of 11 synovial membranes and five rheumatoid nodules. RESULTS Cells carrying the Epstein-Barr virus were not detected using EBER and BHLF1 oligonucleotides in...

Background: Breast cancer is the malignancy in humans and other mammals. Several risk factors are involved in their appearance such as higher hormone levels and obesity. Identification of a mouse mammary tumor virus supports a viral etiology for breast tumors in animals. Viruses have been implicated in the development of various cancers, but viral induction for formation breast cancer is contro...