Accurate in vivo predictions of intestinal absorption low solubility drugs require knowing their physiologically relevant dissolution media. Aspirated human fluids (HIF) are the gold standard, followed by simulated HIF fasted and fed state (FaSSIF/FeSSIF). However, current characterization data vary, there is also some controversy regarding accuracy FaSSIF FeSSIF for predicting drug HIF. This s...

The solubility of a ”heavy” alkane (solute) in ”light” (solvent) is generally temperature dependent. Moreover, it determined by the molar masses solute and solvent. In current paper, published data for binary normal-alkane mixtures reviewed (solid-liquid equilibrium). A total 43 unique solute-solvent data-sets, obtained from 24 experimental studies, are collected presented systematic manner. Ba...

Alex Avdeef [1] and Samuel Yalkowsky [2] have independently studied the solubility and ionization properties of an investigational drug (NSC-639829). In the study conducted by Avdeef and coworkers, the pKa value derived from Henderson-Hasselbalch (HH) equation was 4.70, which was different from the value of 3.76 as determined experimentally by the Yasuda-Shedlovsky plot using the pKa values obt...

The influence of nonlinear sorption and prior sorbate/ sorbent exposure time on transport of fenuron and monuron in laboratory soil columns was studied. Observed monuron breakthrough curves (BTCs) were well described using a two-region transport model with a single mass-transfer rate coefficient, independent of prior sorbate/sorbent exposure history. However, levels of soil-resident postelution...

In the present work a simple but selective reversed-phase high performance liquid chromatographic method (HPLC) was developed for analysis of the nematic liquid crystal mixture E7 to precisely determine the composition of the liquid crystal mixture used in PDLC films preparation. Ultra-violet absorption spectrophotometry (UV) experiments were carried out to determine the HPLC detection waveleng...

In a study of the solubility of crystalline forms of cholesterol in various solvents, the solubilities (per cent by weight) of cholesterol needles and hydrated plates at 38#{176} were, respectively, 4.0 and 3.2% in olive oil; 2.6 and 1.9% in tetradecane; 26.2 and 9% in toluene; and 21.0 and 7% in cyclohexane. When these solvents are in equilibrium with an aqueous phase, needles are converted to...

The study of chemical composition of waters in the abandoned open pyrite mine at WieSciszowice (the Rudawy Janowickie Mts., the W Sudetes, SW Poland) has been canied out with the aim of detennining the conditions of mobi1i7..ation and solubility of aluminium. Both the ion activities and the saturation of water samples with respect to mineral phases have been calculated using the WATEQ4F compute...

Abstract This article is the first of three projected IUPAC Technical Reports resulting from Project 2011-037-2-100 (Reference Materials for Phase Equilibrium Studies). The goal this project to select reference systems with critically evaluated property values validation instruments and techniques used in phase equilibrium studies mixtures. report proposes seven liquid–liquid studies, covering ...

The broad-based implementation of thermoelectric materials in converting heat to electricity hinges on the achievement of high conversion efficiency. Here we demonstrate a thermoelectric figure of merit ZT of 2.5 at 923 K by the cumulative integration of several performance-enhancing concepts in a single material system. Using non-equilibrium processing we show that hole-doped samples of PbTe c...