Polyphenols have general health benefits including anti-photoaging influences to counter the negative effects of ultra-violet (UV) rays from solar light (via generation reactive oxygen species (ROS) and oxidative stress (OS)), which leads stimulation matrix metalloproteinases (MMPs) that break down collagen elastin. The changes in elastin represent major factors dermal aging along with a decrea...

n BIOCHEMICAL, MOLECULAR, AND GENETIC MECHANISMS Leucine Differentially Regulates Gene-Specific Translation in Mouse Skeletal Muscle Micah J Drummond, Paul T Reidy, Lisa M Baird, Brian K Dalley, and Michael T Howard 1616 See corresponding commentary on page 1603. Perinatal Brain Docosahexaenoic Acid Concentration Has a Lasting Impact on Cognition in Mice Luis E Lozada, Abhishek Desai, Karl Keva...

Endogenous estrogens are important determinants of breast cancer risk in postmenopausal women. In this study we evaluated the effects of dietary soy isoflavonoids on endogenous estrogen metabolism in a postmenopausal primate model. Ovariectomized female cynomolgus monkeys were randomized to receive one of three diets for 36 months: (i) isoflavonoid-depleted soy protein isolate (SPI-) (n = 29); ...

Phyto-oestrogens are believed to have a range of beneficial effects on predominant Western diseases. A few studies on phyto-oestrogens in milk exist and show that the composition can be affected by feeding. Therefore, the aim was to study how feeding of lucerne and grass/clover silages (GCSs) affects the concentration of phyto-oestrogens in bovine milk. Sixteen Danish Holstein cows were assigne...

Our previous case-control study suggested that equol, a metabolite of isoflavone, has a preventive effect on prostate cancer. To examine the prostate cancer risk based on isoflavone intake and equol production, we carried out a phase II, randomized, double-blind, placebo-controlled trial of oral isoflavone (60 mg/day) for 12 months. The inclusion criteria were Japanese men between 50 and 75 yea...

UNLABELLED Soy isoflavones and their metabolism by intestinal microbiota have gained attention because of potential health benefits, such as the alleviation of estrogen/hormone-related conditions in postmenopausal women, associated with some of these compounds. However, overall changes in gut bacterial community structure and composition in response to addition of soy isoflavones to diets and t...

Urinary isoflavone excretion is used to monitor compliance and examine biological effects. The present study determined if there were alterations in urinary isoflavone excretion following the ingestion of different soya foods and if age and gender potentially modified profiles. Twenty premenopausal women, seventeen post-menopausal women and twenty men received a defined single oral bolus dose (...

BACKGROUND Test results on the bioavailability of isoflavones in the aglycone or glucoside form in Eastern and Western human subjects are contradictory. OBJECTIVE The objective was to investigate the bioavailability of the soy isoflavones daidzein and genistein in American women with typical American dietary habits after ingestion of the aglycone or glucoside form of isoflavones. DESIGN Fif...