Mitotic spindle orientation is used to generate cell fate diversity and drive proper tissue morphogenesis. A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types. Previous research proposed that cortical dynein/dynactin was sufficient to generate forces on astral microtubules (MTs) to orient the spindle, with NuMA acting as a passive tether. I...

Researchers have long been concerned with students’ sleep. In 1913, Terman and Hocking (1) had already raised a number of questions on the subject, namely: "What is the optimum amount of sleep for physicvels (measured by MSLT) in adolescents during a summer holiday camping. Golub has recently (2) found a delay in sleep-wake cycle (SWC) concurrent with the sexual development of Rhesus monkeys (M...

A large recreation value may be expected for a long-distance walking track which allows for hiking and camping in a tropical rainforest environment. When such a resource is new, sufficient data are not available for a primary study. A practical way to obtain a value estimate is by employing benefit transfer procedures. Using a travel cost analysis for the Thorsborne Trail as the transfer source...

Accounts of language acquisition differ significantly in their treatment of the role of prediction in language learning. In particular, nativist accounts posit that probabilistic learning about words and word sequences has little to do with how children come to use language. The accuracy of this claim was examined by testing whether distributional probabilities and frequency contributed to how ...

During 2004-2014, the Democratic Republic of the Congo (DRC) declared 54% of plague cases worldwide. Using national data, we characterized the epidemiology of human plague in DRC for this period. All 4,630 suspected human plague cases and 349 deaths recorded in DRC came from Orientale Province. Pneumonic plague cases (8.8% of total) occurred during 2 major outbreaks in mining camps in the equat...

The global mining industry keeps expanding, and projects are often started in areas previously considered too remote. Due to worker beliefs about safety, and the diversity of cultures in remote projects, the measurement and management of human fatigue is complex. This paper reports on five studies from companies in Kalimantan, the Indonesian part of the island of Borneo, where workers had been ...

BACKGROUND Asymmetric cell divisions are involved in the divergence of the first two lineages of the pre-implantation mouse embryo. They first take place after cell polarization (during compaction) at the 8-cell stage. It is thought that, in contrast to many species, spindle orientation is random, although there is no direct evidence for this. METHODOLOGY/PRINCIPAL FINDINGS Tubulin-GFP and li...

The Everest climbing season that has just ended was marred by the worst accident in the mountain’s history. On 18 April 2014, 16 Nepalese sherpas died in an avalanche, and subsequent climbing expeditions were cancelled. 2 The deaths of men from poor communities, hired to perform dangerous tasks for the sake of mountain climbing, provoked controversy. I used data on deaths above base camps from ...