Abstract Estrogen, the major female sex hormone has been linked with immune response disparity between males and females. However, exact mechanism by which estrogen impacts our ability to fight viral infection development of immunologic memory remains unknown. CD8 T cells represent primary protective against viruses cancer. Here we aim understand how cell mediated antiviral is regulated estroge...

A set of isoflavononid and flavonoid analogs was prepared evaluated for estrogen receptor α (ERα) ERβ transactivation anti-neuroinflammatory activities. Structure–activity relationship (SAR) study naturally occurring phytoestrogens, their metabolites, related isoflavone revealed the importance C-ring isoflavonoids ER activity selectivity. Docking suggested putative binding modes daidzein 2 dehy...

Previous studies in ovine uterine arteries have demonstrated that sex steroid hormones upregulate extracellular signal-regulated kinase 1/2 expression and downregulate the protein kinase C signaling pathway, resulting in the attenuated myogenic tone in pregnancy. The present study tested the hypothesis that chronic hypoxia during gestation inhibits the sex steroid-mediated adaptation of extrace...

background and objective: breast cancer is the commonest cancer of indian women. estrogen and progesterone expression is seen in benign breast lesions and in breast carcinoma associated with good prognostic parameters and it correlates well with response to hormone therapy. although a lot of studies have been conducted in the past on hormone receptor expression in breast cancer and few have cor...

the hippocampal system plays an important role in memory function. neurohormones like androgens and estrogens that syntheses in hippocampus have an important role in learning and memory. many biological effects of estrogens in the brain via estrogenic receptors (ers) are investigated. the current research has conducted to assess the effect of estrogenic receptors on spatial discrimination in ra...