S t u d y s e l e c t i o n Published and unpublished studies were selected if they were randomized controlled trials (RCTs) of ≥ 1 year of duration in postmenopausal women; compared etidronate (using the intermittent cyclic method at 400 mg/d for 14 to 20 d, and then using calcium or vitamin D, or both) with placebo, calcium, vitamin D, or calcium plus vitamin D; and evaluated outcomes of frac...

Hyperphosphatasia, or hereditary bone dysplasia with hyperphosphatasaemia, is a rare genetic disorder which is characterised by failure to transform woven into lamellar bone. Clinical, radiological and histological features establish the diagnosis, fractures, deformities, diffuse sclerosis on radiographs and high serum alkaline phosphatase being characteristic. We report the case of a 27-year-o...

The bisphosphonates comprise a class of therapeutic agents that inhibit bone resorption and are frequently used in medicine in the treatment of among others osteoporosis, skeletal metastases from solid tumours, hypercalcaemia of malignancy, multiple myeloma and Paget’s disease [1]. First synthesised in 1865 in Germany, their use had been primarily industrial as these molecules proved to be powe...

BACKGROUND This study was aimed at comparing the safety of bisphosphonates in women with osteoporosis by application of equivalence testing. METHODS Gastrointestinal and renal side effects were evaluated based on information published in randomized controlled trials. RESULTS The data on gastrointestinal side effects (47 trials) indicated that alendronate, risedronate etidronate, and zolendr...

The pharmacokinetics of 186Re-HEDP, a radiopharmaceutical for palliative treatment of metastatic bone pain, was investigated in 11 patients (17 studies) who suffered from metastatic breast or prostate cancer. Half-life times of 186Re in three blood fractions (whole blood, plasma and plasma water) were 40.1 +/- 5.0, 41.0 +/- 6.0 and 29.5 +/- 6.4 hr, respectively. Time-dependent increase in plasm...

Sixteen patients with seropositive rheumatoid arthritis were treated with 20 mg disodium aurothiomalate (Myocrisin) weekly for six months. Disease activity was assessed before and after treatment. Plasma profiles and urinary excretion of free thiomalate were measured in all patients after the initial injection and again at six months in the 12 patients remaining on therapy. No difference was fo...

In the present study the smear layer dissolution kinetics of 18% etidronate (HEBP), 9% HEBP, and 17% ethylenediaminetetraacetic acid (EDTA) on human dentin were quantitatively and longitudinally analyzed by using a single-tooth comparative model. Coronal dentin disks were prepared from 3 maxillary human molars. A standardized smear layer was produced on the pulpal side of each disk. The smear l...