Frailty, multi-system dysregulation following multiple life stressors, is associated with age and vulnerability to negative health. Our model posits that variables such as age and sex affect biocultural changes resulting from lifestyle and alter frailty. We assessed frailty with a four-factor index. We expand understanding of frailty by examining associations with demographic, health, and lifes...

Copulas and frailty models are important tools to model bivariate survival data. Equivalence between Archimedean copula models and shared frailty models, e.g., between the Clayton-Oakes copula model and the shared gamma frailty model, has often been claimed in the literature. In this note we show that, in both models, there is indeed the well known equivalence between the copula functions; the ...

The failure processes of heterogeneous repairable systems with minimal repair assumption can be modelled by nonhomogeneous Poisson processes. One approach to describe an unobserved heterogeneity between is multiply the intensity function a positive random variable (frailty term) gamma distribution. This assumes that relative frailty distribution among survivors independent age. Where are being ...

BACKGROUND Malnutrition represents an important issue in older adults; unfortunately, there is lack of data concerning this topic in Lebanon. This paper aims to provide a description of nutritional status and its correlates in older adults living in long stay institutions situated in Beirut. METHODS This cross-sectional study was conducted in three long stay institutions in Beirut in 2012. Th...

In survival analysis, frailty models are potential choices for modeling unexplained heterogeneity in a population. This tutorial presents an overview and general framework of frailty modeling and estimation for multiplicative hazards models in the context of biomedical and genetic studies. Other topics in frailty models, such as diagnostic methods for model adequacy and inference in frailty mod...

Introducing a random effect into the Cox model is a useful tool forbuilding hierarchical families of univariate semiparametric regressionsurvival models. Hougaard [1984] used the Laplace transform to buildfrailty models with explicitly defined survival functions and random ef-fects. The family derived from stable distributions was then extended[Aalen, 1992] to frailty va...

BACKGROUND Frailty is a multidimensional syndrome characterized by loss of physiologic and cognitive reserves that confers vulnerability to adverse outcomes. We determined the prevalence, correlates and outcomes associated with frailty among adults admitted to intensive care. METHODS We prospectively enrolled 421 critically ill adults aged 50 or more at 6 hospitals across the province of Albe...

BACKGROUND/AIMS The fatigue, resistance, ambulation, illnesses, and loss of weight (FRAIL) scale is a screening tool for frailty status using a simple 5-item questionnaire. The aim of this study was to evaluate the clinical feasibility and validity of the Korean version of the FRAIL (K-FRAIL) scale. METHODS Questionnaire items were translated and administered to 103 patients aged ≥ 65 years w...