نتایج جستجو برای: evolving enhancer protein

تعداد نتایج: 1295154  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Ilias K Nolis Daniel J McKay Eva Mantouvalou Stavros Lomvardas Menie Merika Dimitris Thanos

We examined how remote enhancers establish physical communication with target promoters to activate gene transcription in response to environmental signals. Although the natural IFN-beta enhancer is located immediately upstream of the core promoter, it also can function as a classical enhancer element conferring virus infection-dependent activation of heterologous promoters, even when it is pla...

Journal: :Molecular and cellular biology 1994
A J Henderson S McDougall J Leiden K L Calame

Three high-affinity binding sites for the GATA family of transcriptional regulators have been identified within the T-cell receptor beta-chain (TCR beta) transcriptional enhancer, and their functional significance has been determined in an effort to understand the T-cell specificity of the enhancer more fully. One site, TE4, is important for activity of the enhancer in T cells. Neither site TE1...

Journal: :The Journal of Experimental Medicine 2001
Boris Reizis Philip Leder

The expression of the pre-T cell receptor alpha (pTa) gene occurs exclusively in immature T lymphocytes and is regulated by poorly defined mechanisms. We have analyzed the role of the upstream enhancer in pTa expression using conventional and bacterial artificial chromosome (BAC) reporter transgenes. The deletion of the enhancer completely abolished the expression of pTa BAC reporter in transge...

Journal: :Molecular and cellular biology 1996
S W Hiebert W Sun J N Davis T Golub S Shurtleff A Buijs J R Downing G Grosveld M F Roussell D G Gilliland N Lenny S Meyers

The t(12;21) translocation is present in up to 30% of childhood B-cell acute lymphoblastic and fuses a potential dimerization motif from the ets-related factor TEL to the N terminus of AML1. The t(12;21) translocation encodes a 93-kDa fusion protein that localizes to a high-salt- and detergent-resistant nuclear compartment. This protein binds the enhancer core motif, TGTGGT, and interacts with ...

Journal: :The Journal of endocrinology 2009
Katsumori Segawa Morihiro Matsuda Atsunori Fukuhara Kentaro Morita Yosuke Okuno Ryutaro Komuro Iichiro Shimomura

Adiponectin is exclusively expressed in adipose tissue and secreted from adipocytes, and shows anti-diabetic and anti-atherogenic properties. However, the precise transcriptional mechanism of adiponectin remains elusive. In this study, the 5' flanking promoter region of human adiponectin gene was analyzed using UCSC genome browser, and a 10 390-bp fragment, containing an evolutionally conserved...

2016
Tianjiao Zhang Yang Hu Xiaoliang Wu Rui Ma Qinghua Jiang Yadong Wang

Many disease-related single nucleotide polymorphisms (SNPs) have been inferred from genome-wide association studies (GWAS) in recent years. Numerous studies have shown that some SNPs located in protein-coding regions are associated with numerous diseases by affecting gene expression. However, in noncoding regions, the mechanism of how SNPs contribute to disease susceptibility remains unclear. E...

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