The components of the Bacillus anthracis exotoxins, protective antigen (PA), lethal factor (LF), and edema factor (EF), from 24 isolates were separated by isoelectric focusing gel electrophoresis and detected by Western blot with monoclonal antibodies. Only two isoforms each were observed for PA and EF. Four isoforms were identified for LF. The biological activities of both lethal toxin and ede...

Immunologic cross-reactivity between Streptococcus pyogenes type A exotoxin (erythrogenic toxin) and Staphylococcus aureus enterotoxins B and C1 was demonstrated by Ouchterlony double diffusion, Western immunoblot, and immunodot analyses. Specific antiserum to type A streptococcal exotoxin reacted more strongly with staphylococcal enterotoxin B than with enterotoxin C1. The reactivity of type A...

Severe sepsis with multi-organ failure is associated with a high mortality rate. This case report highlights the challenges and modalities available in the management of a lady with refractory shock and disseminated intravascular coagulation (DIC) due to toxic shock syndrome (TSS) from genital tract sepsis. Early surgical intervention to remove the source of infection, the use of recombinant ac...

Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, and debilitating skin disease of the hair follicle unit that typically develops after puberty. The disorder characterized by comedones, painful inflammatory nodules, abscesses, dermal tunnels, scarring, with predilection for intertriginous areas body (axillae, inguinal, anogenital regions). Recruitment neutrophils to HS lesion...

The T3SS is a needle-like nanomachine that injects virulence proteins (exotoxins) directly into eukaryotic cells to initiate infection. Fore effector proteins of P. aeruginosa, ExoS, Exo T, Exo U, and ExoY, modulate a variety of cellular functions for the pathogen's benefit via their enzymatic activity. P. aeruginosa is invasive or cytotoxic to host cells, depending on the T3SS effectors encode...

It was resolved, therefore, to ascertain whether S. hIrnolyticus could be found in the throat cultures of those who were )ick positive, and further to determine whether the various strains could be separated into scarlatinal and non-scarlatinal types. As it has already been shown (Smith, 1926, 1927, Griffith, 1926, James, 1926) that scarlatinal types cannot be distinguished by agglutination and...