INTRODUCTION Oxybutynin and tolterodine are two drugs widely used for the management of overactive bladder and urge urinary incontinence. The once-daily, extended-release formulations benefit from being well tolerated and efficacious. However, their costs, compared with generic immediate-release (IR) oxybutynin, are significantly greater. This study compared the cost effectiveness of oxybutynin...

In discussions on the development of the institutional framework for decisions on the benefit package of social health insurance in Germany, the English National Institute for Clinical Excellence (NICE) is considered as either a good or a bad example for reform. According to this study, the procedures and criteria applied by NICE for making health care coverage decisions are legitimate. Procedu...

BACKGROUND To update a cost-effectiveness analysis of rotavirus vaccination in the Netherlands previously published in 2011. METHODS The rotavirus burden of disease and the indirect protection of older children and young adults (herd protection) were updated. RESULTS When updated data was used, routine infant rotavirus vaccination in the Netherlands would potentially become an even more cos...

Printed materials have been a primary mode of communication in public health education. Three major approaches to the development of these materials--the application of characteristics identified in the literature, behavioral strategies and marketing strategies--have major implications for both the effectiveness and cost of materials. However, little attention has been directed towards the cost...

Health economic decision models are subject to various forms of uncertainty, including uncertainty about the parameters of the model and about the model structure. These uncertainties can be handled within a Bayesian framework, which also allows evidence from previous studies to be combined with the data. As an example, we consider a Markov model for assessing the cost-effectiveness of implanta...

This paper is the first to conduct cost-effectiveness analyses of bariatric surgery comparing obese patients with obesity-related diseases to obese people without comorbidities across different BMI categories, using the meta-analysis results of surgery outcomes for our effectiveness inputs. We find that surgery treatment is in general cost-effective for people whose BMI is greater than 35 kg/m(...

OBJECTIVES To explore how the cost effectiveness of a behaviour-change prevention programme for sexually transmitted infection (STI) varies with the phase of an STI epidemic. METHODS A model of STI transmission and standard methods of cost-effectiveness analysis was used to examine the cost effectiveness of a hypothetical, behaviour-change intervention initiated at various phases of an STI ep...

of ischemic stroke moderate and severe degrees of severity using a drug cerebrolysin compared with standard therapy, cost-effectiveness ratios (CER) were obtained 419656 RUB (6920 EUR) and 563183 RUB (9287 EUR), respectively. ConClusions: The standard therapy in combination with drug cerebrolysin has a lower CER compared with standard therapy, therefore, it is a dominant technology from the per...