The HESR facility will be built in the frame of the FAIR project. For the reason of safety radiation fields have to be considered for the building design. Radiation produced by lost proton and antiproton beams can be dangerous for personnel and equipment. Thus a beam line, where those losses can appear, must be properly shielded by concrete, soil, etc. A FLUKA [1] simulation was done to estimat...

Finding the right dose of a novel treatment is one of the most important tasks in early drug development. However, there is often uncertainty about the form of the relationship between dose and patient response at the time that the dose-finding trials are designed. In this presentation we develop Bayesian adaptive designs for Phase II cross-over trials conducted to estimate the minimum effectiv...

The environmental neutron spectrum has been measured at Zacatecas City in Mexico. Neutron spectrum was unfolded from count rates obtained with a multisphere neutron spectrometer with a LiI(Eu) scintillator. With the spectrum information the ambient dose equivalent and the isotropic effective dose were calculated. A model based upon the geomagnetic latitude and the altitude above sea level, that...

The antileukemic activity (medium effective dose, MED) of a set of 37 carboquinones was modeled using a combination of the electrotopological state (E-state) and molecular connectivity indices with multiple linear regression. A four-variable model gave good statistics: r2 = 0.90, s = 0.21. Using the leave-one-out method, the cross-validation statistics indicate a model useful for prediction: r2...

Planned in-situ radiosensitization may improve the therapeutic ratio of image guided I prostate brachytherapy. Spacers used in permanent implants may be manufactured from a radiosensitizer-releasing polymer to deliver protracted localized sensitization of the prostate. Such devices will have a limited drug-loading capacity, and the drug release schedule that optimizes outcome, under such a cons...

Coals mined in some regions of the Transdanubian Middle Mountains in Hungary have elevated concentrations of Ra. The slags and ashes derived from these coals have been used as building material for schools and kindergartens. As the Ra reached up in these waste products of coal-firing systems, the gamma dose contribution in the buildings, which contained them, was calculated. In these places the...

Introduction In this study, effective dose equivalent for the public due to internal exposure to 222 radon ( 222 Rn) was evaluated in three regions of Ramsar, a northern coastal city in Iran. Materials and Methods Measurements were carried out using a radon monitoring device. Outdoor and indoor radon concentrations were measured within 24 hours with an integration interval of 3 hours. Regions w...

Four patients with nicorandil induced ulceration are described, and the literature on the subject is reviewed. Nicorandil induced ulcers are very painful and distressing for patients. Clinically they appear as large, deep, persistent ulcers that have punched out edges. They are poorly responsive to topical steroids and usually require alteration of nicorandil treatment. The ulceration tends to ...