In the crystal structure of the title compound, C(21)H(18)ClFO(3)·0.5C(7)H(8), the toluene solvent mol-ecules occupy special positions on centres of symmetry, and consequently are disordered across this site. The cyclo-hexene ring has a slightly distorted sofa conformation; the two benzene rings are inclined by 72.90 (7)° and their planes make dihedral angles of 30.09 (10) (chloro-phen-yl) and ...

A method for quantitatively predicting the hepatic clearance of drugs by UDP-glucuronosyltransferases (UGTs) from in vitro data has not yet been established. We examined the relationship between in vitro and in vivo intrinsic clearance by rat hepatic UGTs using 10 drugs. For these 10 drugs, the in vitro intrinsic clearance by UGTs (CL(int, in vitro)) measured using alamethicin-activated rat liv...

Ion doping can modify the cell structure, which is one of effective methods to improve electrochemical performance. However, there a lack research on F- and Cl-doped LiNi0.8Co0.1Mn0.1O2. In this paper, effects F Cl properties structure LiNi0.83Co0.08Mn0.08O2 during process lithium removal were studied by first-principles calculation based density functional theory. The results show that reduces...

It is well known that the Clifford algebra Cl p,q associated to a nondegenerate quadratic form on R n (n = p + q) is isomorphic to a matrix algebra K(m) or direct sum K(m) ⊕ K(m) of matrix algebras, where K = R, C, H. On the other hand, there are no explicit expressions for these isomorphisms in literature. In this work, we give a method for the explicit construction of these isomorphisms. Let ...

Current researches have showed that N3, N5-diaryl-2, 6-dimethyl -1, 4-dihydropyrine-3, 5- dicarboxamide analogues demonstrate notable anti-tubercular activity. In this study, Hantzsch condensation was used to design and synthesize new analogues of dihydropyridine (DHP). Different diary carboxamides were inserted at positions 3 and 5 of the DHP ring. 4(5)-chloro-2-ethyl-5(4)-imidazolyl moiety wa...

In this work, stabilized f-ZrO 2 ceramic samples with the compositions of (Zr 0.82 Y 0.09 Eu )O 1.91 , Tb and 0.045 were studied. The elemental composition was studied by electron probe microanalysis, luminescent properties local cathodoluminescence (CL). An analysis 3+ CL spectra confirmed stabilization cubic phase in ceramics at room temperature. study obtained spectra, 5 D 4 - 7 F band lumin...

We modeled nevirapine (NVP) pharmacokinetics in HIV-infected Malawian patients to assess the relationship between drug exposure and patient characteristics, genetic polymorphisms, and development of hypersensitivity reaction (HSR). One thousand one hundred seventeen patients were prospectively recruited and followed for 26 weeks with multiple or single serum samples obtained in a subset of pati...