A substantial number of mutations have been identified in voltage-gated sodium channel genes that result in various forms of human epilepsy. SCN1A mutations result in a spectrum of severity ranging from mild febrile seizures to Dravet syndrome, an infant-onset epileptic encephalopathy. Dravet syndrome patients experience multiple seizures types that are often refractory to treatment, developmen...

Information was sought on whether B cells undergo abnormal differentiation in F1 leads to parent chimeras (irradiated parental-strain mice reconstituted with F1-hybrid bone marrow cells). As assessed by collaborative responses to sheep erythrocytes in vivo, three different types of T cells restricted to interaction with strain a H-2 determinants were shown to collaborate as effectively with het...

This article describes how a mixture of two densities, f0 and f1, may be decomposed into a different mixture consisting of three densities. These new densities, f+, f−, and f=, summarize differences between f0 and f1: f+ is high in areas of excess of f1 compared to f0; f− represents deficiency of f1 compared to f0 in the same way; f= represents commonality between f1 and f0. The supports of f+ ...

The role of immunity to intracellular Ags in resistance to infection by Yersinia is not well established. The enteropathogenic bacteria Yersinia pseudotuberculosis and Yersinia enterocolitica actively translocate Ags to the cytosol of eukaryotic cells. Whereas Yersinia pestis does not always express the requisite cellular adhesins, results have varied as to whether similar cytosolic translocati...

The ATPase activity of rat liver Fl is inhibited by a number of covalent labeling agents which are reported to have preferential specificities for either tyrosine, carboxyl, or amino residues. Two types of agents, ie. trypsin and sulfhydryl reactive compounds, are without effect on the ATPase activity of F1. In this study, the effect of trypsin on energy-linked functions catalyzed by the mitoch...

Hypertension and stroke in spontaneously hypertensive rats (SHR) were investigated genetically using stroke-prone SHR (A3), stroke-resistant SHR (C) and their hybrids, hybrid of A3 and C (F1), offspring of F1 X F1 (F2), and those of backcrossing of F1 to the respective parental strains, BC(F1 X A3) and BC(F1 X C). The average blood pressure measured without anesthesia increased in the following...

introduction: we have recently reported the presence of two potassium currents with 598 and 368 ps conductance in the rough endoplasmic reticulum (rer) membrane. the 598 ps channel was voltage dependent and atp sensitive. however, the 368 ps channel was rarely observed and its identity remained obscure. since cationic channels in intracellular organelles such as mitochondria and rer play import...

We define and study the category Rep(Q, F1) of representations of a quiver in Vect(F1) the category of vector spaces ”over F1”. Rep(Q, F1) is an F1–linear category possessing kernels, co-kernels, and direct sums. Moreover, Rep(Q, F1) satisfies analogues of the Jordan-Hölder and Krull-Schmidt theorems. We are thus able to define the Hall algebra HQ of Rep(Q, F1), which behaves in some ways like ...

Given two maps f1, f2 : M −→ N between manifolds of the indicated arbitrary dimensions, when can they be deformed away from one another? More generally: what is the minimum number MCC(f1, f2) of pathcomponents of the coincidence space of maps f ′ 1 , f ′ 2 where f ′ i is homotopic to fi, i = 1, 2 ? Approaching this question via normal bordism theory we define a lower bound N(f1, f2) which gener...