The importance of an accurately fitting fixed prosthesis or a removable prosthesis is essential for the success of the restoration. Ill-fitting prosthesis may cause mechanical failures of the prosthesis, implant systems, or biologic complications of the surrounding tissue. There are several causes related to improper seating of the prosthesis. Some of which can be corrected and the others need ...

BACKGROUND The challenge of understanding factors influencing compliance with injectable treatments is critical as injectable biologics/medications become more common. OBJECTIVE Understanding compliance issues for long term self-injectable treatments, using a chronic condition (osteoporosis) as a model. RESEARCH DESIGN A qualitative study to generate hypotheses regarding compliance issues f...

Design and assessment activities associated with a biopharmaceutical process are performed at different levels of detail, based on the stage of development that the product is in. Preliminary "back-of-the envelope" assessments are performed early in the development lifecycle, whereas detailed design and evaluation are performed prior to the construction of a new facility. Both the preliminary a...

OBJECTIVES Examine the probability of new active substances (NASs) approved in Canada between 1 January 1997 and 31 March 2012 acquiring a serious postmarket safety warning. DESIGN Cohort study. DATA SOURCES Annual reports of the Therapeutic Products Directorate and the Biologic and Genetic Therapies Directorate; evaluations of therapeutic innovation from the Patented Medicine Prices Review...

Development of simple-to-use, cost-effective risk assessments is a current research necessity in Ergonomics. Direct measurements and observational methods are usually considered more reliable and objective than retrospective self-assessment but the more subjective methods are often the only feasible way to evaluate exposure to health risks – particularly in large field studies. This paper discu...

The scope of the present paper is the derivation of a merit function which predicts the visual perception of LED spot lights. The color uniformity level Usl is described by a linear regression function of the spatial color distribution in the far field. Hereby, the function is derived from four basic functions. They describe the color uniformity of spot lights through different features. The re...

The persistence of socioeconomic inequalities in health, even in the highly developed 'welfare states' of Western Europe, is one of the great disappointments of public health. Health inequalities have not only persisted while welfare states were being built up, but on some measures have even widened, and are not smaller in European countries with more generous welfare arrangements. This paper a...

A second National Science Foundation-sponsored workshop on Conceptual Assessment in Biology was held in January 2008. Reports prepared for the workshop revealed that research groups working in a variety of biological sciences are continuing to develop conceptual assessment instruments for use in the classroom. Discussions at this meeting largely focused on two issues: 1) the utility of the back...

Lawyers make short work of “clinical experience” testimony by defendants and expert witnesses in suicide malpractice cases. Clinical experience, unaided by evidence-based research, can be idiosyncratic, insufficient, uninformed, or just plain wrong when applied to complex, fact-specific suicide cases. Both in the clinical setting and in providing expert witness testimony, clinical experience ca...

The objective of this research was to estimate the relative magnitude of effects included in contemporary groups (CG) and their interactions with adjusted and actual 120 d and 210 d weights in 72,731 male and female Nelore calves born from 1985 to 2005 in 40 herds from PMGRN (Genetic Improvement Program of Nelore). Ten models with different CG structures were compared. The analyses were done us...