2-Chlorodeoxyadenosine (2-CDA) is an adenosine deaminase resistant analogue of deoxyadenosine which has shown clinical activity in human hematologic neoplasms. The exact mode of action of this drug remains the subject of investigation. We applied the Differential Staining Cytotoxicity (DiSC) assay to 50 human tumour specimens obtained from patients with a variety of hematologic malignancies to ...

BACKGROUND The purpose of this study was to investigate whether uncovertebral joint ossification was a risk factor for axial symptoms (AS) after cervical disc arthroplasty (CDA). METHODS This retrospective study included 52 consecutive patients who underwent CDA for single-level cervical disc disease. To examine possible risk factors for AS after CDA, univariate and multivariate logistic regr...

In this study, a systematic review was carried out with the aim of analyzing terms, definitions, dimensions, and prevalence rates cyber dating abuse (CDA). After analysis, term is considered as most appropriate complete definition construct provided, along related dimensions. order to synthesize victimization CDA, meta-analysis 16 studies also out, including 14,235 participants, based on suitab...

In the research, speech “Women’s rights are human rights” by Hillary Clinton will be analyzed in light of critical discourse analysis (CDA) as both theory and method to reveal how power ideology embedded language particular relation between society general. Initially, theoretical framework CDA, concepts presented. The social context women’s position including past nowadays is also revealed. res...

The coupled data assimilation (CDA) system consisting of ocean, sea-ice, and atmosphere components with the Beijing Climate Center (BCC) System Model has been developed to provide reliable analyses atmosphere, sea-ice states. It incorporates ocean temperature/salinity profiles, sea surface temperature, level height, concentration observations at a daily frequency, reanalysis 6-hourly frequency....

By site-directed mutagenesis on human cytidine deaminase (CDA), five mutant proteins were obtained: C65A, C99A, C102A, E67D and E67Q. The three cysteine mutants were completely inactive, whereas E67D and E67Q showed a specific activity about 200- and 200000-fold lower, respectively, than the wild-type CDA. Zinc analysis revealed that only E67D, E67Q and C65A contained 1 mol Zn2+/mol subunit as ...

2-Chlorodeoxyadenosine (2-CdA), a purine analog, has become universally accepted as the agent of choice in treating hairy cell leukemia (HCL). However, few studies have reported long-term outcomes after 2-CdA treatment. Between January 1990 and June 2003, 86 consecutive patients with HCL were treated with a single 7-day course of 2-CdA by continuous infusion at a dose of 0.1 mg/kg per day. Of t...

In the debate over high frequency trading, the frequent call (Call) mechanism has recently received considerable attention as a proposal for replacing the continuous double auction (CDA) mechanisms that currently run most financial markets. One natural question, which has begun to spur the development of new models, is the e↵ect of competition between platforms that use these two di↵erent mecha...