The cell surface receptor AvB6 is epithelial specific, and its expression is tightly regulated; it is low or undetectable in adult tissues but has been shown to be increased in many different cancers, including pancreatic, cervical, lung, and colon cancers. Studies have described AvB6 as a prognostic biomarker linked to poor survival. We have recently shown the feasibility of imaging AvB6 in vi...

For over two decades, Flux Balance Analysis (FBA) has been successfully used for predicting growth rates and intracellular reaction in microbiological metabolism. An aspect that is often omitted from this analysis, segregation or heterogeneity between different cells. In work, we propose an extended FBA method to model cell size distributions balanced conditions. Hereto, a mathematical descript...

The fungal genus Candida includes common commensals of the human mucosal membranes, and most prevalently isolated species, C. albicans , poses a threat candidemia disseminated infection associated with an unacceptably high mortality rate immense $4 billion burden (US) yearly. Nevertheless, demand for vaccine remains wholly unfulfilled increasingly pressing. We developed double-peptide construct...

In this paper, we consider the Minimum Reaction Insertion (MRI) problem for finding the minimum number of additional reactions from a reference metabolic network to a host metabolic network so that a target compound becomes producible in the revised host metabolic network in a Boolean model. Although a similar problem for larger networks is solvable in a flux balance analysis (FBA)-based model,...

Accurate mapping of temporal changes in urban land use and land cover (LULC) is important for monitoring urban expansion and changes in LULC, urban planning, environmental management, and environmental modeling. In this study, we present a feature-based approach of the decision tree classification (FBA-DTC) method for mapping LULC based on spectral and topographic information. Landsat 5 TM and ...

Exploiting the outstanding performance of optical atomic clocks for improved timekeeping, relativistic geodesy, and fundamental physics beyond standard model demands comparing distant state-of-the-art clocks. Interferometric fiber links have been demonstrated as an eminent method such frequency comparisons over distances up to thousands kilometers. However, distances, attenuation mandates signa...

To assess the role of rigid bronchoscopy in children with tracheobronchial foreign body aspiration (FBA) a retrospective study was carried out Pediatrics Ward Bakhtawar Amin Trust Hospital & Medical Dental College Multan for 1 year. A total 80 aged 6 months to 15 years were included study. Data collected from medical histories patients. Rigid performed all patients under anesthesia. All dat...

Drought and food security crises heighten risks to lives livelihoods in East Africa. In recent years, a shift towards acting advance of such events has gained momentum, notably among the humanitarian development community. This is premised on tools that link climate forecasts with pre-agreed actions funding, known as Forecast-based Action (FbA), or anticipatory action more widely. While FbA app...

Staphylococcus aureus is one of the most common nosocomial sources of soft-tissue and skin infections and has more recently become prevalent in the community setting as well. Since the use of penicillins to combat S. aureus infections in the 1940s, the bacterium has been notorious for developing resistances to antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA). With the per...

This paper presents feature-based alignment (FBA), a general method for efficient and robust model-to-image alignment. Volumetric images, e.g. CT scans of the human body, are modeled probabilistically as a collage of 3D scale-invariant image features within a normalized reference space. Features are incorporated as a latent random variable and marginalized out in computing a maximum a posterior...