Additive manufacturing (AM) technologies have been successfully applied in various applications. Fused deposition modeling (FDM), one of popular AM techniques, is most widely used method for manufacturing of plastic materials. Due to the poor strength properties of pure plastic materials, there is a critical need to improve mechanical properties for FDMfabricated pure plastic parts. One of the ...

To investigate the effects of collagen cross-linking using glyceraldehyde on the biomechanical properties of the sclera and the axial elongation of form-deprived myopia in the guinea pig. Thirty-six guinea pigs were randomly assigned to four groups: FDM (form-deprived myopia); FDMG (form-deprived myopia treated with glyceraldehyde); FDMS (form-deprived myopia treated with 0.9% isotonic sodium c...

In this paper, we describe a systematic multi-objective problem solving approach, simulataneosly minimizing two conflicting goals average surface roughness ‘Ra’ and build time ‘T ’, for object manufacturing in FDM process by usage of evolutionary algorithms. Popularly used multi-objective genetic algorithm NSGA-II and recently proposed multi-objective particle swarm optimization (MOPSO) algorit...

Polymethylmethacrylate (PMMA) is a biocompatible alloplastic material used in craniofacial reconstruction and as bone cement and antibiotic-impregnated spacers in orthopaedics. The polymerization of PMMA in-situ causes tissue necrosis and other complications due to the long surgical times associated with mixing and shaping the PMMA. PMMA is a thermoplastic acrylic resin suitable for extrusion i...

BACKGROUND Current American Thoracic Society and American Association for Respiratory Care guidelines for the delivery of aerosol agents such as methacholine chloride (MC) for bronchoprovocation testing require the use of pneumatic jet nebulizers that have well-defined droplet size and mass output. A recently developed disposable, breath-actuated nebulizer (AeroEclipse) may offer bronchoprovoca...

Functional diffusion mapping (fDM) is a cancer imaging technique that quantifies voxelwise changes in apparent diffusion coefficient (ADC). Previous studies have shown value of fDMs in bevacizumab therapy for recurrent glioblastoma multiforme (GBM). The aim of the present study was to implement explicit criteria for diffusion MRI quality control and independently evaluate fDM performance in a m...

Discussed is here the multipoint meshless finite difference method (MMFDM) following the original Collatz [2] multipoint concept, and the essential ideas of the meshless FDM [3]. The Collatz approach was based on interpolation, regular meshes and the local formulation of b.v. problems. On the other hand in the MFDM we deal with the moving weighted least squares (MWLS) approximation, arbitrarily...

This article describes on-going work using an object-oriented database, P/FDM, to build 3D homology models of β-trefoil proteins such as Interleukin-1 (IL-1), by exploiting existing structural data from known structures of the same fold. The model-building procedure is based on the powerful querying capabilities of P/FDM that allows data access, navigation, and computation to be mixed freely an...

Cryptosporidium is globally established as a contaminant of drinking and recreational waters. A previously described cell culture infectivity assay capable of detecting infectious oocysts was adapted to quantify viable oocysts through sporozoite invasion and clustering of foci. Eight experiments were performed by using oocysts less than 4 months of age to inoculate host HCT-8 cell monolayers. O...

The aim was to investigate the effects of the GABAB receptor antagonist, CGP46381, on form-deprivation myopia (FDM) in guinea pigs. Twenty-four guinea pigs had monocular visual deprivation induced using a diffuser for 11 days (day 14 to 25). The deprived eyes were treated with daily subconjunctival injections (100 μl) of either 2% CGP46381, 0.2% CGP46381, or saline or received no injection. The...