OBJECTIVE To evaluate the efficacy of different antipyretic agents and their highest recommended doses for preventing febrile seizures. DESIGN Randomized, placebo-controlled, double-blind trial. SETTING Five hospitals, each working as the only pediatric hospital in its region. PARTICIPANTS A total of 231 children who experienced their first febrile seizure between January 1, 1997, and Dec...

Febrile seizures are the most common seizures seen in children younger than 5 years old. Out-of-hospital and emergency department providers need to be familiar with the principles of the evaluation and management of this common disorder. Most febrile seizures are brief, do not require any specific treatment or extensive workup, and have a benign prognosis. Recognizing the pattern of a simple fe...

OBJECTIVE The relationship between iron deficiency anemia and febrile convulsions has been examined in several studies with conflicting results. The authors aimed to evaluate the relation, if any, of iron status with first febrile convulsion. METHODS In this case-control study, the authors assessed 200 children with a diagnosis of first febrile convulsion, aged between 6 months and 5 years, d...

OBJECTIVES To examine the degree and frequency of reductions in hippocampal volume in patients with temporal lobe epilepsy with and without a history of febrile seizures. METHODS In vivo measures of hippocampal volume were computed from three dimensional gradient echo (FLASH) images in 44 patients undergoing comprehensive evaluations for epilepsy surgery. Twenty one patients (48%) reported a ...

PURPOSE Febrile seizure, the most common type of pediatric convulsive disorder, is a benign seizure syndrome distinct from epilepsy. However, as epilepsy is also common during childhood, we aimed to identify the prognostic factors that can predict epilepsy in children with febrile seizures. METHODS The study comprised 249 children at the Korea University Ansan Hospital who presented with febr...

To ascertain whether LP was justifiable in cases of first simple febrile seizure, the records of128 such patients were critically reviewed in this study. It was evident that in 90% of those who received cerebrospinal fluid examination as a routine work up, lumbar puncture could have been avoided if the definition of simple febrile seizure was adhered to and the history and clinical finding...

PURPOSE Febrile seizures are induced by fever and are the most common type of seizures in children. Although numerous studies have been performed on febrile seizures, their pathophysiology remains unclear. Recent studies have shown that cytokines may play a role in the pathogenesis of febrile seizures. The present study was conducted to identify potential links between serum interleukin-1beta (...

Febrile seizures occur between the age of 3 months and 5 years with a temperature of 38 degrees C or higher, and are either simple or complex. Eight gene loci have been identified to be associated with certain cases of autosomal dominant familial febrile seizures, and 12 genes have been associated with some of the familial epilepsy syndromes that can start with febrile seizures. The mutations a...