Recent evidence indicates that transthyretin (TTR), the major transport protein for thyroxine [1] and retinol binding protein [2], plays important roles in amyloidβ (Aβ) metabolism. Transthyretin has been demonstrated to bind Aβ in vitro [3,4] and in vivo [5,6], colocalize in Aβ plaques and within neurons containing intracellular Aβ [7], and recent evidence suggests it might act as a transport ...

In the core mammalian circadian negative feedback loop, the BMAL1-CLOCK complex activates the transcription of the genes Period (Per) and Cryptochrome (Cry). To close the negative feedback loop, the PER-CRY complex interacts with the BMAL1-CLOCK complex to repress its activity. These two processes are separated temporally to ensure clock function. Here, we show that histone deacetylase 3 (HDAC3...

Transmit diversity techniques provide attractive solutions for increasing downlink capacity in 3G systems within low-mobility environments. Open-loop and closed-loop transmit diversity modes with two transmit antennas have already been included into 3GPP WCDMA Release 4, and at the moment schemes exploiting a larger number of transmit antennas are being developed. This paper analyzes the perfor...

Biological networks often involve many parameters, and the importance of these parameters in determining system behaviors must be assessed in order to gain deep insight into designing principles of living organisms. However, many parameters cause the biological system behaviors vary extensively, therefore it is difficult to analyze the effect of individual parameters in a systematic way. In thi...

Active vibration isolation from an arbitrarily, structurally complex receiver is considered with respect to the impacts of structure flexibility on the openand closed-loop system characteristics. Specifically, the generally weak influence of flexibility on the open-loop transfer function in case of total force feedback, in contrast to acceleration feedback, is investigated. The open-loop system...

In this paper, the problem of stabilizing an open-loop unstable second-order system with time delay is considered. A constant feedback gain is utilized to stabilize the system. Using a modified version of Hermite-Biehler Theorem, which is applicable to quasi-polynomialsthe complete set of stabilizing constant feedback gains for open-loop unstable plants, is determined. The desired closed-loop p...

Postural sway is considered to have two fundamental stochastic components, a slow non-oscillatory component and a faster damped-oscillatory component. The slow component has been shown to account for the majority of sway variance during quiet stance. Postural control is generally viewed as a feedback loop in which sway is detected by sensory systems and appropriate motor commands are generated ...

Postural sway is considered to have two fundamental stochastic components, a slow nonoscillatory component and a faster damped-oscillatory component. The slow component has been shown to account for the majority of sway variance during quiet stance. Postural control is generally viewed as a feedback loop in which sway is detected by sensory systems and appropriate motor commands are generated t...

In earlier papers ([2], [3], [6]) feedback guided loop scheduling algorithms have been shown to be very effective for certain loop scheduling problems which involve a sequential outer loop and a parallel inner loop and for which the workload of the parallel loop changes only slowly from one execution to the next. In this paper the extension of these ideas the case of nested parallel loops is in...