A bioassay for possible carcinogenicity of clonitralid was conducted using Osborne-Mendel rats and B6C3F1 mice. Clonitralid was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. Twenty animals of each sex and species were placed on test as controls. The time-weighted average high and low dietary concentrations of clonitralid w...

Michler's ketone, a dye intermediate and derivative of dimethylaniline, was selected for bioassay by the National Cancer Institute because of the elevated incidence of bladder cancer noted among dye manufacturing industry workers. A bioassay for the possible carcinogenicity of technical-grade Michler's ketone was conducted using Fischer 344 rats and B6C3F1 mice. Michler's ketone was administere...

A bioassay of a solution of 30 percent b-nitrostyrene and 70 percent styrene for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. The solution of the two test materials in corn oil was administered by gavage, at either of two dosages, to groups of 50 male and 50 female animals of each species. The high and low dosages utilized in the study were, respectively, 300 a...

Article deals with the problem of reducing level stress and improving growth development young animals during weaning from a nursing female. For this purpose, it is proposed to use an extract larvae tobacco hawkmoth (Manduca sexta), containing ecdysone juvenile hormone. We studied anxiety in experimental setup light-dark test. Authors conclude that hawk moth caterpillars reduces animals. This m...

OBJECTIVE We studied the effect of swimming on the somatic and bone growth of female rats. METHODS 40 neonate Wistar female rats were separated into: monosodium glutamate group (GluM, n = 20) and received MSG solution (4.0 mg/g) on alternate days during the first 14 days after birth, and Saline group (SAL, n = 20) which received saline solution for the same period of time and at the same dose...

Objective(s): The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats. Materials and Methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/...

The bioassay of nithiazide for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. Nithiazide was administered in the diet, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The high and low concentrations of nithiazide utilized were, respectively, 1,250 and 625 ppm for rats and 5,000 and 2,500 ppm for mice. Dosed rats receiv...

The stress response is a multifaceted physiological reaction that engages a wide range of systems. Animal studies examining stress and the stress response employ diverse methods as stressors. While many of these stressors are capable of inducing a stress response in animals, a need exists for an ethologically relevant stressor for female rats. The purpose of the current study was to use an etho...

Ferric nitrilotriacetate (Fe-NTA) induces renal proximal tubular necrosis, a consequence of lipid peroxidation, that finally leads to a high incidence of renal adenocarcinoma in rats and mice. Male animals are much more susceptible than female animals to both effects. Moreover, the distribution of the susceptible proximal tubules is different between male and female animals. The present study i...

BACKGROUND Malachite green chloride is a dye used to prevent fungus infections in commercial fisheries. Leucomalachite green is formed from malachite green and remains in the tissues of exposed fish. We studied the effects of malachite green on female rats and female mice, and the effects of leucomalachite green on male and female rats and female mice, to identify potential toxic or cancer-rela...