This study was performed with a laboratory-scale fixed-bed bioreactor degrading a mixture of aromatic compounds (Solvesso100). The starter culture for the bioreactor was prepared in a fermentor with a wastewater sample of a care painting facility as the inoculum and Solvesso100 as the sole carbon source. The bacterial community dynamics in the fermentor and the bioreactor were examined by a con...

This study reports on an original concept of additive manufacturing for the fabrication of tissue engineered constructs (TEC), offering the possibility of concomitantly manufacturing a customized scaffold and a bioreactor chamber to any size and shape. As a proof of concept towards the development of anatomically relevant TECs, this concept was utilized for the design and fabrication of a highl...

Background: Nowadays, the optimization of the culture conditions in bioreactors is considered as an approach to produce secondary metabolites such as thebaine. Thebaine is the dominant alkaloid in Iranian poppy that is used as a precursor for the synthesis of analgesic compounds. Objective: Optimization of culture conditions of Papaver bracteatum adventitious roots in bioreactor for the scale...

The Biosorption property of S. cerevisiae for chromium uptake was investigated in an immobilized cell bioreactor. Saw dust was utilized as the solid bed in the reactor. Adsorption of S. cerevisiae on saw dust obeys a first order reaction kinetic up to 6 hours. The immobilized biomass particles are porous and exist in the new generation of biological adsorbent. Chromium biosorption was studied i...

Vascular endothelial growth factor (VEGF) has been strongly implicated in the development of choroidal neovascularization, which is seen in age-related macular degeneration. This study investigates whether retinal cells cultured individually or as cocultures with endothelial cells and maintained in the horizontally rotating bioreactor will express more VEGF and VEGF receptors. We measured the e...

Engineered tissue grafts have been manufactured using methods based predominantly on traditional labour-intensive manual benchtop techniques. These methods impart significant regulatory and economic challenges, hindering the successful translation of engineered tissue products to the clinic. Alternatively, bioreactor-based production systems have the potential to overcome such limitations. In t...

The expanded granular sludge bed bioreactor appears today as a cheap, robust and more popular technology because it operates using a fluidized bed, which allows increasing in organic load and in cell retention times, generating higher treatment efficiencies (up to 95 %) and renewable energy (i.e., biogas, biomethane, and biohydrogen). Nevertheless, the efficiency of this bioreactor mainly depen...

One of the major steps toward the industrialization of the microbial product(s) is to optimize the cultivation conditions at the large-scale bioreactor and successfully control the microbial behavior within a large scale production environment. Statistical Design of Experiment was proven to optimize a vast number of microbial processes to achieve robustness and explore possible interactions...

a laboratory stirred tank bioreactor with six single and dual-impeller configurations was tested to obtain the optimum operating conditions for future biological processes. six impeller combinations consisting of three basic impeller types, namely rushton turbine (rt), pitched 4blade (p4b) and pitched 2blade (p2b) downward flow were investigated in 1.77 l bioreactor working volume. power consum...