Salivary gland tumours (SGT) constitute a diagnostically challenging group of neoplasms with frequently unpredictable clinical outcome. The proliferation rate facilitates the identification of aggressive SGT. The Chromatin Assembly Factor-1 (CAF-1) is a major epigenetic regulator of nuclear chromatin organization during DNA replication. It plays a critical function in human tumourigenesis and h...

Although T regulatory cells (Treg) are essential for the prevention of autoimmune diseases, their immunoregulatory function restrains the induction of immune responses against cancer. Thus, development of inhibitors of FOXP3, a key transcription factor for the immunosuppressive activity of Treg, might give new therapeutic opportunities. In a previous work we identified a peptide (named P60) abl...

Cobalt (Co2+) is required as an essential trace element to a variety of metabolic functions such as the synthesis of vitamin B12 in mammals. It was proven that cobalt passes through the placenta to the fetus. Cobalt possesses toxic effect on embryo. Also, Chromium (Cr3+) as an essential element for both animal and human nutrition has antioxidative capacity. In this study we examined the effects...

The aim of this study was to compare the in vitro wear and superficial roughness of four materials (Delton Dyract Flow, Dentsply; Filtek Flow, Vitremer, 3M ESPE) used as fissure sealant in 32 extracted human molars divided in four groups (n = 8) after abrasion with toothbrush/dentifrice. Impressions of each occlusal surface were made to analyze wear and circular specimens were prepared to analy...

Background and Aim: Composite placement poses many challenges, especially in the gingival floor with dentinal margins. Microleakage is one of the factors affecting the longevity of dental restorations. We aimed to compare the microleakage of cavities filled with bulk-fill composite at enamel and dentinal margins. Materials and Methods: In this experimental study, a total of 102 sound human pre...

BACKGROUND Moisture control is very important in restorative procedures in dentistry. Use of hemostatic agents helps control moisture; however, they might result in changes on enamel and dentin surfaces, affecting composite resin bond quality. The aim of this in vitro study was to evaluate the marginal microleakage of two different composite resins with the use of three different hemostatic age...

We found high levels of the c-src gene product in neuroendocrine tissues from adult animals. To understand the role of this proto-oncogene product, the subcellular localization of p60 c-'~ was studied in neuroendocrine tissue from adrenal medulla. The results indicate that p60 ~-'~ was highly enriched in chromaflin granule membranes, in stable association with a protein of 38 kD. The complex wi...

The aim of this study was to evaluate the bond strengths of composite restorations made with different filler amounts and resin composites that were photoactivated using a light-emitting diode (LED). Thirty bovine incisors were selected, and a conical cavity was prepared in the facial surface of each tooth. All preparations were etched with Scotchbond Etching Gel, the Adper Scotchbond Multipurp...

OBJECTIVE The objective of this study was to evaluate the diametral tensile strength (DTS) and Knoop hardness (KH) of direct (Filtek Z350-3M/ESPE and Charisma-Heraeus Kulzer) and indirect composites (Sinfony-3M/ESPE and Signum-Heraeus Kulzer) kept in storage for two periods of time, 24 hours and 10 months, in distilled water. METHODS Twenty-five specimens of each material were prepared. DTS (...