The object of this study is to evaluate the influence of silymarins from cultivated and wild Silybum marianum L. plants with different content of flavonolignans, especially silibinin on serum lipids levels and on the experimental atherosclerosis development in rabbits fed on high cholesterol-diet (HCD). Forty eight male six-months-old white New Zealand rabbits (1.8-2 kg) were randomly assigne...

Background and objectives: The seed extract of Silybum marianum contains seven flavonolignans known collectively as silymarin. These metabolites can be produced in hairy root cultures of S. marianum. The effect of different physical factors can change root biomass and silymarin production which has been investigated in the present study. Methods<...

the object of this study is to evaluate the influence of silymarins from cultivated and wild silybum marianum l. plants with different content of flavonolignans, especially silibinin on serum lipids levels and on the experimental atherosclerosis development in rabbits fed on high cholesterol-diet (hcd). forty eight male six-months-old white new zealand rabbits (1.8-2 kg) were randomly assigned ...

Consumption of alcohol is part of the human lifestyle almost worldwide. Ethanol oxidation gives rise to the generation of free radicals, both in vitro and in vivo, and such events are associated with the induction of DNA damage, for example, the DNA strand breaks and modification of DNA bases occurs. Oxidative damage to DNA is of a great importance because of the growing recognition that such d...

Recent studies have shown an increase in alcohol-related digestive and liver diseases as alcohol consumption grew during the COVID-19 pandemic. Patients may embrace milk thistle—which has been promoted a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion—to protect from environmental toxins. With hundreds of years history treatment wide range disorders gallbladder prob...

BACKGROUND Silybum marianum L. (Milk thistle) is native to the Mediterranean basin and is now widespread throughout the world. It's sprout is used as a herbal medicine for the treatment of liver disease for centuries. The seeds of milk thistle contain silymarin, an isomeric mixture of flavonolignans [silybin, silychristin, and silydianin]. Silymarin acts as a strong anti-hepatotoxic. OBJECTIV...

Biomolecules can be oxidized by free radicals. This oxidative damage has an important etiological role in aging and the development of diseases like cancer, atherosclerosis, and other inflammatory disorders. Synthetic antioxidants, like butylated hydroxyanisole, are good free radical scavengers, however, the synthetic antioxidants can be carcinogenic. Therefore, there is an increasing interest ...

introduction due to scarcity of forage and water resources and high feed prices in iran, it seems that the utilization of native and cheap forage resources for ruminants is important. the milk thistle (silybum marianum) is distributed in different regions of iran included: gonbad kavoos, gorgan, nodeh kalardasht, dareh hezareh, dasht mugan, poshtkoh, mollassani, shush, hamidieh, ramhormuz, izeh...