BACKGROUND Neurotransmitters had progressive effects on various cancers via their different type of receptors. OBJECTIVE This study was conducted to determine the pattern of serotonin receptors, respectively, 5HTR2A and 5HTR3A gene expression in MCF-7 cells and evaluate their selective antagonist effects on them. METHOD RT-PCR was performed to determine the pattern of serotonin receptor gen...

BACKGROUND Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Emerging data suggests that T helper 17 (Th17) cells play a pathogenic role in SLE and the increased number of these cells correlates with disease activity. In recent years, 1α, 25-dihydroxyvitamin D3 (1,25VitD3) has been considered as an immunomodulatory factor. OBJECTIVE To investigate the effect of 1,25VitD3...

Detailed analysis of elastic light scattering by spheres in FlowCytometers shows unexpected Lorenz-Mie scattering patterns. The complete scattering matrix S of spheres was measured. Two parameter scatterplots with xand ycoordinates determined by the S11 + Sij and S11 Sij values were obtained. Samples of spheres with very narrow size distributions were analyzed and produced unexpected two parame...

Luteolin (LUT), a flavone, which is universally present as constituent of medicinal plants as well as some vegetables and spices, has been demonstrated display specific anti-carcinogenic effects. However, the mechanisms by which LUT inhibits human osteosarcoma growth remain unknown. The effects of LUT on cell growth in human osteosarcoma U2OS cells were measured by MTT assay and flowcytometry. ...

chronic lymphocytic leukemia (cll) remains an incurable disease that requires innovative new approaches to improve therapeutic outcome. many ferula species, including f. asa-foetida, synthesize terpenyloxy coumarins. one of these coumarins is umbelliprenin, which has been implicated with induction of apoptosis in some cancer cell lines.     in this study induction of apoptosis by umbelliprenin ...

Development of new tuberculosis vaccine will be an important strategy to eliminate tuberculosis in kwashiorkor. Previous research showed that 38-kDa Mycobacterium tuberculosis protein is one of the potent immunogen. However, the role of oral immunization with 38kDa Mycobacterium tuberculosis protein to the number of lymphocytes in the rat model of kwashiorkor is still unknown. We used kwashiork...

The relationship between the percent phagocytosis of platelets by differentiated THP-1 cells was examined using flowcytometry and the peripheral platelet counts as well as platelet-associated IgG (PAIgG) in 36 patients with secondary dengue virus (DV) infections. The percent phagocytosis and the levels of PAIgG were significantly increased in these patients during the acute phase compared with ...

We consider axiomatically the problem of estimating the strength of a conditional dependence relationship PY |X from a random variables X to a random variable Y . This has applications in determining the strength of a known causal relationship, where the strength depends only on the conditional distribution of the effect given the cause (and not on the driving distribution of the cause). Shanno...

Central nervous system infiltration by acute leukemia is a poor prognosis variable, and conventional cytology the gold standard for its diagnosis; technique highly specific but not sensitive. To improve diagnosis, flow cytometry has been used in different studies, showing greater sensitivity detection of leukemic cells. This study aimed to evaluate presence tumor cells flowcytometry cytology, c...