Combinations of caspofungin and posaconazole were evaluated by fractional inhibitory concentration index against 119 Candida glabrata isolates. Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility against this organism.

A total of 100 HIV sero-positive patients with oral lesion/lesions suggestive of oropharyngeal candidiasis were studied. Candida species were isolated from 61 patients. Out of 61 isolates, 43 (70.49%) isolates were of Candida albicans and 18 (29.50%) isolates were of non albicans species. Out of 43 isolates, 2 (4.65%) isolates of Candida albicans and out of 18 isolates, 4 (22.2%) isolates of no...

Background & objectives: Fungal infections are increasing very rapidly. Candida is a major pathogen involved and constitutes a part of normal microflora of humans. This organism is a leading agent associated with blood stream infections. The present study involves phenotypic characterization of Candida isolates. The isolates were obtained from National Culture Collection of Pathogenic Fungi at ...

Denture-related stomatitis (DRS) is the most common condition affecting removable-denture wearers, and Candida albicans the most frequent pathogenic agent. Systemic antifungal treatment is indicated but recurrences are frequent. The aim of this study was to characterize the oral load, fluconazole susceptibility profile and genotypic variability of oral C. albicans isolates from patients with DR...

Abstract Dermatophytosis is a major health problem all over the world including Pakistan. This first report of detection dermatophytes and their antifungal drug resistance in Northern Western parts A total 154 samples were collected from different hospitals Khyber Pakhtunkhwa, out them 136 found positive. Tinea corporis (35%) was most predominant type infection followed by capitis (22%). The fu...

We compared the in vitro activity of a new triazole, D0870, with those of fluconazole, itraconazole, and ketoconazole against 41 clinical isolates of fluconazole-resistant Candida belonging to nine different species. The 50% inhibitory concentrations (IC50s) were determined by a microdilution method with morpholinopropanesulfonic acid (MOPS)-buffered RPMI medium and an inoculum of approximately...

OBJECTIVES Candida glabrata is one of the most common causes of Candida bloodstream infections worldwide. Some isolates of C glabrata may be intermediately resistant to azoles, with some strains developing resistance during therapy or prophylaxis with fluconazole. In this study, we used a proteomic approach to identify differentially expressed proteins between fluconazoleresistant and -suscepti...

Presently appearance of resistance to antifungal agents among Aspergillus species is dramatically increasing. The objective of this study was to look at the in vitro activities of antifungal drugs against Iranian clinical (from nail, bronchoalveolar lavage, paranasal sinus) isolated A. flavus strains. The susceptibility of 45 aflatoxigenic and non-aflatoxigenic Aspergillus flavus strains were e...

OBJECTIVES The in vitro antifungal activity of posaconazole was compared with that of fluconazole and amphotericin B. MATERIALS AND METHODS A microdilution method (M27-A2) was used with 331 clinical yeast isolates. RESULTS The geometric mean MICs of posaconazole, fluconazole and amphotericin B were 0.16, 0.91 and 0.15 mg/L, respectively. Posaconazole was markedly more active than fluconazol...

INTRODUCTION Candida albicans is responsible for superficial or systemic infections known as candidiasis, which may be found in infected tissue as unicellular budding yeasts, hyphae, or pseudohyphae. In this study, the effects of both fluconazole and itraconazole antifungal agents on the hyphal formation and genotypic characterization of C. albicans isolates classified as either susceptible or ...