Abnormal renovascular resistance and glomerular filtration rate are characteristic of established hypertension and may also be involved in its pathogenesis. To determine renal and body fluid correlates of the predisposition to high blood pressure, we examined 100 healthy young adults with high or low blood pressure. Within each group, half had parents with high blood pressures, and half had par...

The effects of acute bilateral ureteral obstruction (BUO) of 18-h duration on deep nephron and collecting duct function were studied by micropuncture in 11 weanling rats. After release of BUO glomerular filtration rate was reduced (178+/-15 vs. 1,343+/-119 mul/min per g kidney weight in shams), while urine flow was increased averaging 17.5+/-1.3 vs. 6.8+/-0.72 mul/min per g kidney weight in con...

In cake filtration processes, where particles in a suspension are separated by forming filter on the medium, resistances of and medium cause specific pressure drop which consequently defines process energy effort. The micromechanics formation (interactions between particles, fluid, other medium) must be considered to describe pore clogging, growth consolidation correctly. A precise 3D modeling ...

Flow of tubule fluid to the macula densa is part of a proposed feedback loop for autoregulation of glomerular filtration rate. In the present study, autoregulation of single nephron filtration rate was tested in the presence and the absence of flow to the macula densa in the rat. Filtration rates were measured at elevated arterial blood pressures caused by carotid occlusion and vagal section an...

The particles in exhaled breath provide a promising matrix for the monitoring of pathological processes in the airways, and also allow exposure to exogenous compounds to be to assessed. The collection is easy to perform and is non-invasive. The aim of the present study is to assess if an exogenous compound-methadone-is distributed in the lining fluid of small airways, and to compare two methods...

Tubular fluid flow, urine osmolality, and pH were selectively altered to determine the relative protective roles of these factors in a rat model of acute urate nephrophathy. Various prehyper uricemic conditions were established in five groups of animals: (a) normopenic Wistar rats given no pretreatment (Group I); (b) Wistar rats given acetazolamide, 20 mg/kg, and isotonic NaHCO3 to produce urin...

Although the calcium channel blocker diltiazem has been shown to be an effective antihypertensive agent, its effect on renal function, salt and water excretion, and body fluid composition has not been well characterized in patients with primary hypertension. Therefore, these parameters were prospectively studied in 18 subjects with primary hypertension after placebo and 8 weeks of diltiazem mon...

This approach was also first described in 1978 by Henderson [16 ]. In this pilot investigation, the reinfu-sion fluid was prepared off-line by dialysis fluid filtration through hollow fibre ultrafilters made of XP-50 membrane and collected in sterile glass carboys before

In this paper, a mathematical model of the process fluid filtration in underground layered formations is considered and numerically solved as raw material for generating electrical energy. The objects filter are anomalously structured Newtonian fluids. Computational algorithms built using iteration, direct streaming differential sweep methods. An analysis numerical solution problem has been car...

The term "extracorporeal therapy" means a medical treatment utilising an extracorporeal circuit. Blood, plasma or another body fluid is passed through the extracorporeal purification device, where the toxic substances are separated and the purified fluid returns to the body. A range of extracorporeal therapies are available at present, based on physical (dialysis or filtration) or physicochemic...